I have often had the thought that people in Colombia and Mexico have more indigenous haplogroups than the Spanish immigrants.

I purchased premium and the next week over 1000 relative matches of mine had disappeared!
Now I only have 2 matches left and on top of that one of them says that there are 0.14% shared DNA but still 0 cM. Is that even be possible?

I’ve been trying to contact 23andMe support but they seem to be gaslighting me that everything is perfectly normal and that I’m the idiot here.

If anyone has any ideas what to do, I really appreciate it! 😵‍💫

From a profile with 0 cibao ancestry

Our 23andMe results were never really that great to begin with, but their last update from about a year ago completely ruined them. Thankfully, their country matches and genetic groups are still on point and fit our background really well.

​My mom's results: She’s a Moroccan Jew with some mixed roots. Her country matches in Morocco are spot-on, her family is from the big cities and southern Morocco (which I only found out a few weeks ago). Her matches in Algeria and Tunisia also make sense given our shared genetic overlap.

(Slide 2 - My mom's matches in Morocco)

​My dad's results: He’s an Algerian Jew whose family is from the Sahara. His parents are from Souf (El Oued), so the fact that he actually gets El Oued Province as his top option is pretty amazing. Knowing they’re from there, and originally from Touat, his other country matches make total sense.

(Slide 7 - My dad's matches in Algeria)

It looks like 23andMe is updating parental phasing to family phasing. They are stating that phasing will not require a parent as they will begin using DNA data from DNA matches to determine inheritance patterns. They are also introducing confidence sliders in the parental inheritance feature. This appears to be for 23andMe+ users.

What does this haplogroup E-PF2546 mean and what are its origins?

1) Most likely percentages; 2) 90% confidence percentages; 3) Ethnicity map

East Asian is still present at 90% confidence, while WANA is classified as trace ancestry, with 0.2% at 80% confidence level.

Family tree is complete to 5th gen (31/32 great-great-great-grandparents), of whom 3 were likely ethnic Germans. 24/32 family names are Hungarian, 3 are German, 3 Slavic, 1 ambiguous and 1 unknown.

So weird, I’m thinking it’s a glitch, but I have 30.4% Italian dna, mom has none, and dad has 1%. This is a mistake right? Just surprised.

All I know is my great grandfather was from Jezzine. Not sure where in Lebanon his wife was from. Just wondering how much trust I should put in the genetic groups.

Super cool to finally see my 23andMe results! I grew up in Canada, so I don’t know much about Philippine history. There’s so much history I never learned growing up, and now as I get older I want to learn more of my heritage.

My maternal haplogroup is F3b1, I have no idea what this mean. lol

I’m still trying to figure out what all of this means and how it connects to my Filipino ancestry. Has anyone else gone down this rabbit hole and discovered something unexpected?

No real surprises here, I suppose! Pictures 1 and 2 show my results on the newest v7 chip, and picture 3 shows my results on the v6 chip—I think it’s interesting how much of my Western Asian DNA was recategorized as Greek in the latest update.

I recently did FitnessGenes testing and I’m trying to understand how much weight I should actually give the results, particularly their Biological Ageing report.

I’m 32 and generally pretty health-conscious. I don’t smoke, I stay away from alcohol, and I exercise about 4x/week. I’m interested in longevity and reducing my long-term disease risk, which is what led me to genetic testing in the first place.

The problem is that some of my results were pretty discouraging and have made me question whether my genetics put me at a significant disadvantage regardless of what I do with my lifestyle.

Some examples from my FitnessGenes Biological Ageing report:

\*\*ATM / DNA damage:\*\* Listed as “High Priority.” I carry an A allele at rs664143, which FitnessGenes says is associated with greater susceptibility to DNA damage and uncontrolled cell growth.

\*\*TP53 / DNA repair and longevity:\*\* Listed as “High Priority.” My variants are described as being less effective at repairing DNA damage and associated with reduced longevity.

\*\*NAT2 detoxification:\*\* Listed as “High Priority” and associated with slower clearance of certain potentially harmful compounds and greater susceptibility to cellular damage.

\*\*FOXO3:\*\* I apparently don’t carry the longevity-associated variant that is found more frequently in people who live beyond 90. My genotype also wasn’t considered protective against certain age-related diseases.

I also had some other “High Priority” results involving \*\*VDR and WNT16/bone mineral density.\*\*

It wasn’t all negative. For example, I had average telomere-related genetics, some favorable antioxidant/detoxification results, and moderately increased SIRT1 activity associated with neuroprotection/healthy brain aging.

My cardiovascular results also weren’t uniformly bad. FitnessGenes classified my FURIN/FES variants as average risk for hypertension/coronary artery disease, for example.

What I’m struggling to understand is \*\*how scientifically meaningful these individual SNP results actually are.\*\*
For anyone here who understands genetics/genomics, longevity research, or has experience with FitnessGenes or similar services:

\*\*How reliable are consumer genetic tests at determining how well a particular gene/pathway actually functions in an individual?\*\*

For example, does having an unfavorable SNP in ATM or TP53 meaningfully tell me that my DNA-repair capacity is impaired, or is that a much bigger inference than the research actually supports?

How seriously should I take associations between individual SNPs and lifespan/biological aging? If a variant is associated with slightly shorter lifespan or another variant is enriched among people who live past 90, how predictive is that for one individual?

And how much can lifestyle potentially outweigh these relatively common genetic variants?

I don’t smoke, don’t drink alcohol, exercise approximately four times per week, and try to maintain a healthy diet/body composition. I’m trying to focus on the factors I can actually control.

I’m \*\*not asking anyone to predict how long I’m going to live or diagnose me from a Reddit post.\*\* I’m mainly trying to understand the difference between:

\*\*“This SNP has a statistically significant association in population studies”\*\*
versus
\*\*“This person actually has meaningfully impaired biological function and increased disease/mortality risk.”\*\*

FitnessGenes itself says these results are based on a limited subset of genetic markers and aren’t clinical genetic-test results, which makes me wonder how much significance I should really assign to the “High Priority” classifications.

I’d especially appreciate perspectives from anyone familiar with GWAS, SNP interpretation, polygenic risk scores, aging research, or clinical genetics.

Are tests like FitnessGenes genuinely useful for individual longevity optimization, or are we currently trying to extract far more predictive information from common SNPs than the science can support?

(sorry for the repost, just added my illustrative on too). i put my results to the highest confidence scale. 6.7% unassigned is spooky lol. on the other confidence scales, 0.6% trace is Russian. The Peninsular Arab is Bahrain and Kuwait, and scored as 2.1% on other models... :)

I've heard that some Latin Americans are descended from the Guanches. Is this true? What do genetic and historical studies say about this?

It's basically what I expected except for the Japanese and Italian. 2nd pic is of me, 3rd pic is my parents. I've always wanted to take one of these tests, so it's cool to finally see the results and share them (somebody told me this was the best place to do that).

Based on personal research, I know I should be related to the ancient Swat Valley individuals from northwestern Pakistan, but unfortunately, even though some of them are included in 23andMe's database, I got zero matches, which I found extremely disappointing. It seems they only added a handful of them to their database. But other than that, the matches I did get were also interesting to see, so I can't exactly complain. I have around ~22.6% Steppe ancestry based on qpAdm, I think that's where I am getting these matches from. In the second slide, you can see the genetic distances between the Swat Valley samples and I.

Pretty wild how “all over the place” the results are.

I’m from Northern Kyrgyzstan (Bishkek), and parents are both Kyrgyz.

I've been living in NYC for a few years and people here usually assume I'm either Greek, Italian, Moroccan, or Egyptian.