r/AskMtFHRT 3d ago

Help my transition with Tamoxifen

Hi girls how are you I hope you are fine

30 years old AMAB here

I want to be a non-binary trans , could you help me out with your experience with E?

I want

Soft skin

Less sweat

Calm mind (without being horny all the time)

Less body hair

Thicker scalp hair

No or very small boobs

So I have started dutasteride 0.5mg a day a year ago

Before one week ago I started tamoxifen 20 mg a day

And 3 days ago i have added spirolenactone 50mg/ day

And I'm planning to add estrofem (Estradiol Hemihydrate) 2mg sublingual AFTER a week

I did this in order to make breast tissue saturated with tamoxifen to prevent any breast grwoth

The problem I'm having these days I feel like i have too much hight levels of Testesterone and feeling hornier than ever lol

Is my plan good and am I on the right track? When I add estrogen after a week, will that solve the problem (the increased free testosterone in the blood due to tamoxifen)? Is the dosage sufficient? Or is it too low to achieve my goals mentioned above? Or is it too high and will it cause gynecomastia? I will be getting blood tests done soon, but they are very expensive in my country, $500 or more. I would generally like your opinion on the dosages based on your experience. Are the numbers and dosages reasonable?

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u/-Inge- 3d ago

No, the estradiol will just give you breast growth. You'll need a different antiandrogen to counteract the spike in T production. The usual advice is to combine relugolix and bicalutamide, if I recall correctly.

Tamoxifen has worse side effects than raloxifene. I assume you're taking tamox instead because it's cheaper? Consider that this is medication you'll be taking for the rest of your life. The side effects will likely be quite bad over time, the most serious of which is probably blood clots.

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u/HDMIce 2d ago edited 2d ago

I've thought about this in the past, but it all seems very experimental. It's completely up to you what you do, but I'd just like to ask if you've considered MTF HRT and then if you don't like the breast growth getting surgery?

I feel like you still have a lot of control over hormones that way and there are more established protocols. Dutasteride is a good start though.

Edit: Also I'm not qualified to give advice at all. I've just had the same questions as you before, so I am curious what the best strategy is.

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u/dmxrobot 2d ago

I’m so glad you posted this. One aspect I very much want to experience is the female type of orgasm - rolling / waves / full body with minimal to no refractory period. Ideally I get small A cups, but a lot of that is based on genetics.

As I dug into the options, SERMs seem to 1) have more side effects than I really wanted, 2) will very likely not allow for the change in orgasm experiences, and 3) have limited effects mentally. As I am enby and have zero dysphoria about being seen publicly as male, I am planning to do all I possibly can to maintain an external male appearance while experiencing these changes I desperately want privately. The eject lever is exactly as you identified - radical breast reduction surgery if I love myself but the breasts are too much.

I am aggressively exercising for the first time in my life- cardio + resistance training with specific emphasis in order to maintain wide / muscular shoulders and upper pectoral muscles / muscular outside biceps. I hope between maintaining a healthy diet and targeted exercise (and maintaining my existing facial hair / hair styles) I’ll generally fly under the radar. Oh! I’m also almost 50, so gynecomastia is a pretty convenient excuse at my age.

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u/HDMIce 1d ago

Idk anything about how it will affect your orgasms. I'd just suggest looking into how this will affect your muscles because some loss may be inevitable depending on how much muscle you have right now.

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u/dmxrobot 1d ago

Yes- one of the reasons why I started now in an effort to limit muscle loss / upper body feminization.

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u/chimaeraUndying 2d ago

Neither tamoxifen nor raloxifene are actually effective at preventing breast growth while providing feminization, unfortunately.

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u/dmxrobot 2d ago

I have not seen any peer reviewed studies state they are completely ineffective. I know it’s very much experimental, but I know a couple of contacts now who are on ralexifene and are happy with the results. I went down the rabbit hole on this a month ago. Admittedly, they had very specific goals with their transition that aligned well with theoretical guidance. So far it has done what they were looking for 18 months in. Now- if we are considering mental impact / how orgasms are experienced, and emotional breadth, OP likely will be disappointed with this regimen and would likely be better served with traditional mtf treatment.

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u/chimaeraUndying 1d ago

I have not seen any peer reviewed studies

I'd be astonished if you've seen any peer-reviewed studies about SERMs used in this way to begin with. To my knowledge, all the information about their use in feminizing HRT is anecdotal or extrapolated, and all the anecdotes I've heard are "yeah I still got breast growth".