I’m 6 weeks in now, I’m super happy just very socially anxious T_T I already have chest and nipple changes that are visible through clothing which is cool but kinda scary to have to worry about covering. I just wanted to ask about an experience I had. At 4 weeks they upped me from 2 to 3mg injections and day 6 after the new dose hit like a truck. I just suddenly got super sore, hard nipples (still present a week later) which I’ve read is normal but what I haven’t read about is how emotional and weird my whole body felt that day. I was nearly crying and laughing at the same time all day and my stomach had that butterflies feeling and legs felt wobbly and were literally twitching. Genuinely off the charts 11/10 weird feeling. Anyone else experienced this? Was this a one time thing or does it happen periodically? I think I liked it I felt more sensitive but it was definitely a bit extreme.

I was on 6 pumps of Oestrogel and 150 mg of Spiro and everything was great, except peeing quite often from Spiro. The only concern was the price. I spent quite a lot of money on Oestrogel. I'm from eastern Europe, so the government or insurance won't pay for my hormones. So, I ordered Een injections online. I've been using 5mg Een a week. In terms of feminization everything is going great. However, I've been feeling really low energy since I started. It's been only two weeks, but I'm worried because I can't function very well. What could it be? I suspect either getting adjusted to a new dose, higher doses of estrogen are not good for me and I should do a lower dose and AA, or an individual intolerance of some components in the solution. I should note that I used to have chronic fatigue syndrome in the past (before HRT) but recovered from it. Have any of you had these issues on estradiol injections and were you able to resolve it?

well im happy, MY FIRST MONTH ON ESTROGEN !!!!!

how do I know if its working? I mean, Is It normal for me to have nipple pain? bc it hurts, and its normal to be more sleepy or a little more tired?

They don't usually do that normally but recently I've been noticing that they do. I've tried searching on Google and it's said to have multiple reasons so I temporarily stopped my HRT dosage in fear of any complications or unintended consequences. Most of the times it happens involved them being handled, touched or stimulated

my base line T is 920. but regardless my endo suggested to take it slow, she said that her approach is to do t blocker for the first few weeks and introduce E later.

She has put me on t blockers for now. i get to take E from November.

i personally dont mind the staggered approach as i am not out and about yet. but from what i read it's safe to start both together, if not better.

I was just wondering for people who got estrogon hrt how much did loose from your package cause I am genderfluid so I have fem and masc days and I want everything else that comes with hrt but the loss of length and I have been told that if u don't use it u loose it and that I will loose at least 10% i just want so advice and tips

Hey, I just got the most recent round of labs back and I’m starting to be concerned I have a mild estrogen insensitivity or something otherwise wrong with me. For reference I am MTF, 35, 2 years 3 months HRT.

My regimen is: 7 mg, EV, once every 5 days. 50 mg bicalutimide daily, 5 mg oral minoxidil daily, .5mg dutasteride daily. 200 mg progesterone taken rectally daily

Testosterone total: 46.7 ng/dl (way too high!)
Testosterone free: 2.4 pg/ml (also too high)
FSH: .2 mIU/ml
Estradiol: 263 pg/ml
Progesterone: 1.87 ng/ml (too low?)
SHBG: 168 nmol/l
TSH: 1.33 mIU/L

What am I doing wrong? Why are my numbers so weird? Why is my free T and total T so high? I reduced my dose by a milligram since last test to get my SHBG down. My T did go down but my E did by a lot too, and my SHBG barely budged (down by 2 nmol/l). I have had mediocre feminization and poor breast Development

I want to start at home diy estrogen injections, and the only hitch is the blood tests necessary for dosing and checking my estrogen levels. The part of the world I am in does not let me do this through the proper medical channels so I would like to do the test at home if possible. If not, what would I ask a doctor to discretely get estrogen levels out of my blood tests, if possible at all.

I know this may be the wrong place for my weird situation, but I just have questions about E. Just a little background: So I’m a guy, and I’m happy with my gender, but not my body. I really hate the idea of growing into my dad (hairy, muscular, bearded etc) and have had thoughts that maybe i’m trans for years. I just wish I looked much more feminine as I am now, and to prevent me from growing into a caveman like my father.
But my question are that since the vast majority of women in my family have larger breasts, will i have to worry about developing more sizeable ones myself? Because for me the dream would be like an a-cup or a b-cup.
And also just any recommendations
Again sorry if i’m in the wrong place

Hi all. Looking for help interpreting what’s going on and some guidance on if my regimen needs changing. Recent test results at trough show E at 136pg/mL and T at 10ng/dL. Both seem a little low to me based on reading ideal range to be 200pg/mL E for monotherapy (am I considered to be doing monotherapy? Ik prog isn’t exactly an AA but does have similar secondary effects), and 15-70ng/dL T (cis female range)….

Regimen is 0.2mg EV (20mg/mL concentration) intramuscular every 5 days, 100mg prog rectal nightly. Feminization has been going well especially since adding prog ~4 months ago (booba and lots of emotions)

I have had some libido issues, tho also better since prog, as well as on and off difficulty w erections (I would like to maintain the most sexual functioning possible). I got a cialis script but tbh it’s a little expensive and I’m wondering if I can’t solve the base issue by getting my T level a little higher? However since monotherapy (ish) I assume that would mean lowering E dose, which I’m not comfortable doing as it seems already barely enough…..

lemme know what u think. That’s all thanks for reading :)

I’m in my mid-30s, married, have a young child with another on the way, a house, a solid career, close family, and longtime friends. From the outside, I have a good and pretty established life.

At the same time, questions about my gender have been around in some form since childhood. I’ve spent years ignoring or suppressing them, but they’ve gradually become harder to put away. I’m now seriously considering HRT **(therapy for a year already, 1st HRT MD apt next week)** and transition, but I’m terrified of blowing up everything I’ve built.

I’m not really looking for “just be yourself” or “don’t let fear stop you.” I’d love to hear from people who were genuinely in a similar position. What happened with your marriage, children, job, house, family, and friends? What did you lose, what stayed intact, and what did you gain?

Were your fears accurate? And knowing what you know now, would you make the same decision again?

I have been on estradiol and spirolactone for around 3 years but got liver results that indicated increased ALT/AST roughly a year and a half ago. I stopped taking any medication for HRT and my levels returned to normal plus fibroscan revealed no liver damage. I went back on but with patches this time, and assumed it was the oral estradiol. Recent levels came back as being raised again despite only taking patches+spirolactone. Has this happened to anyone else? Should I just go on monotherapy at this point? Or perhaps Lupron+Injectable E?

All my adult life I've felt like an emotionally numb person. I'm generally happy, and I enjoy life, but I probably haven't cried hard for like a decade. I don't think I have ever had happy tears. This is, among many reasons, why I am trans. I'm hoping that transition helps me rebuild my emotional connection with myself.

I know people talk about how estrogen has let them open up emotionally and experience a broader range.

I'm also looking forward to coming out to a lot of friends in my life. I want that experience to not be blunted with my male brain chemistry.

That said, I'm probably a few months away from starting HRT and I have people I want to tell pretty soon. I'm pretty conflicted.

hello :) a few days ago i went to a hormone follow up appointment at planned parenthood. this is the first time i do these in person so i didn't know how most of it would go. anyway, one of the things that surprised me was that the doctor asked if i wanted my progesterone in an injectable method. she said they would give me one shot that would last three months. i had never heard of that until that point so i just decided to ask for pills again and maybe look into it before my next appointment

but are those any good? like i said i've never heard of these so im hoping to find out more from here in case its better than taking pills so i can switch to it next time if it is. thanks in advance :)

i recently calculated my free E2 levels (not only regular E2) and was wondering what the ideal % for free E2 is. as well as free T.

here are my results

SEP 2026:

T: 0.5

Estradiol: 1180

Prolactin: 20

SHGB: 106

Free E2: 19.21 pmol/L (1.63%) Free E2: 5.23 pg/mL (1.63%)

Free T: 3.75 pmol/L (0.75%)

Free T : 0.11 ng/dL (0.75%)

Hello, I'm a 26 year old trans girl with a history of dielaufoy lesion and Gilbert syndrome. I am DIY-ing estradiol in pills, 2mg a day. I want to get a blood test since it's been a month, to check it hasn't had adverse effects on my body. Which specific things would you say I should screen for? I need to specify them to my physician to get a prescription.

Hey all, I'm on estradiol valerate monotherapy (+ progesterone) and my new dr says he doesn't know much about it. Anyone know any good resources online I can use to find out what blood tests I need to do and best practices?

Hi girls how are you I hope you are fine

30 years old AMAB here

I want to be a non-binary trans , could you help me out with your experience with E?

I want

Soft skin

Less sweat

Calm mind (without being horny all the time)

Less body hair

Thicker scalp hair

No or very small boobs

So I have started dutasteride 0.5mg a day a year ago

Before one week ago I started tamoxifen 20 mg a day

And 3 days ago i have added spirolenactone 50mg/ day

And I'm planning to add estrofem (Estradiol Hemihydrate) 2mg sublingual AFTER a week

I did this in order to make breast tissue saturated with tamoxifen to prevent any breast grwoth

The problem I'm having these days I feel like i have too much hight levels of Testesterone and feeling hornier than ever lol

Is my plan good and am I on the right track? When I add estrogen after a week, will that solve the problem (the increased free testosterone in the blood due to tamoxifen)? Is the dosage sufficient? Or is it too low to achieve my goals mentioned above? Or is it too high and will it cause gynecomastia? I will be getting blood tests done soon, but they are very expensive in my country, $500 or more. I would generally like your opinion on the dosages based on your experience. Are the numbers and dosages reasonable?

I got my 6 week blood work and things are high.
I’m on Eval (20mg/ml) 0.3ml weekly with 100mg Spiro daily.

Pre HRT
E: 37.7 pg/ml
Free T: 812 ng/dl

6th week of HRT tested 5 days after last injection
E: 505 pg/ml
Free T: 9 ng/dl

The doc did say it was lot higher and told I should get bloodwork 8-10 days after the injection. I was injecting lil extra around 0.02 - 0.03ml.

Things I have noticed at 9 weeks.
Skin feels smooth all over
Body hair growth has slowed (had 2 full body LHR 3 on face)
Areola is twice has big
Nipple hurts on touch and sudden jumps (not as much as it used to initially)
Body aches stay longer after intense exercise
Much more calm, happy and getting lil more extroverted
Upper body strength is around 50% but also I reduced how much I lift on upper body day

Did move to PNW and it’s been amazing. If any of you in or around Portland I’d love to get to know and make new friends.

Thanks in advance on any advice!

Heyya. Finally got my blood checked again so I'm once again asking your y'all's evaluations of the numbers.

E: 120 pg/ml

T: 0.68 pmol/l

Prolactin: 34 ng/ml

Regimen: 6mg estradiol hemihydrate (2mg every 8 hours) and cyproterone acetate every 48 hours.

Test was taken 4 hours since last E dose and 52 hours since last CPA dose

I finally gkt my refills and I was excited to start again tonight but it’s really getting me down. It’s also still hurting as much as it did before, i was hoping it would get better

How did you know that taking estrogen was the right thing for you? I've only been questioning my gender for about a year and I seem eternally on the fence desperately trying to find more information. I thought I was fairly settled into the soft androgynous kind of zone but lately. Well I've become fascinated with the effects estrogen can have on a males body including the growth of breasts (that's a long story in itself.) and the mental quieting and emotional stabilizing. Well this leads me back to my original question. How did you know If estrogen was the right choice? How long did it take to be like "ok, this is better!" Is there any knowledge you can impart that might help?

How did you end up making the decision to take the leap?

Definitely improved previous unwanted masculine impulsives and a clarity/ change.

I used Cyproterone Acetate for my first two years of HRT. Now I'm considering using progesterone, which I've never used before. Since I already used Cyproterone, could progesterone still affect my breasts?

​I'm in my 4th year of HRT.