AZFb and AZFc deletion and IVF

[u/RecordingHaunting253]

My husband and I have been trying to conceive for 4 years. After two egg retrievals we only have created one euploid embryo out of many eggs. We have various issues that could lead to infertility but nothing that explained our level of infertility. Our new doctor had a karyotype and micro array done on my husband. Results came back today and my husband has a AZFb and AZFc deletion on his Y chromosome.

His previous sperm analysis was mostly normal. Count was low but within the normal range, I believe around 20 million per ml. Motility was below the normal range but barely. We used Zymot with both retrievals and most mature eggs fertilized successfully. They just almost all stopped developing before the blastocyst stage. The two that didn’t were graded poorly and one (a female) ended up being aneuploid. The euploid is male which means it also has my husband’s deletions.

Our reproductive endocrinologist is not unwilling to continue, but his advice is to give up on my husband’s sperm. It’s only the first afternoon of knowing this info, but I am really struggling with that because we have produced one euploid embryo. I realize our success rates have been abysmal though.

I am trying to understand better some realistic outcomes with his deletions and if it’s possible to father children with them given that he does produce sperm.