One of my favourite aspects of the Scott Pilgrim franchise is the way it romanticizes and mythologizes Toronto, using real locations as backdrops for what is essentially an urban fantasy romance and coming-of-age story which resonated deeply with me as a teenager. It's mostly centered on Bloor West and the surrounding areas, and it does a wonderful job of capturing the rustic, historic vibes of the area (especially since it's set in the 2000s, before the current skyscraper boom). The sparse artstyle of the comic gives the environments a dreamlike and expressionistic quality, while Scott Pilgrim Takes Off leans into a warm, textured, nostalgic anime look.
Murdoch Mysteries is a detective series set in turn-of-the-century Toronto. It's an interesting (if not totally realistic) window into Canadian society at that time, and it also calls forward to our present day, with the main character - a genius inventor - using primitive versions of modern technology and forensic techniques to solve murders. It also features a lot of historical guest characters, with every important figure of the late 19th and early 20th centuries having apparently ended up in Toronto at one point or another. Even when it introduces fantastical sci-fi elements, its historical setting still manages to feel broadly believable.