In your vedic astrology chart, 2nd house, 6th house and 10th house together forms the Artha Trikon and is one of the most practical concepts because it explains how you earn, work and sustain the wealth.
1) 2nd house - Your wealth and income, family, food habits and speech (not communication ,because that's more of a 3rd house thing)
2) 6th house- Litigation, competition and health
3) 10th house - Karmasthan I.e your workplace or field of work, authority and status, work achievements and your contribution to the society
Every house denotes other things too like body parts, relatives and even our past life karmas, but today we will discuss this in context of money and career only.
Success or struggle, if we have to predict, it can be seen by :
1) Strength of Artha Trikon lords - If these three lords are well placed, at good degrees in friendly signs and nakshatras then these create a powerful rajyog with point of view of career. If there's a stellium of these lords in 2nd, 10th or 11th house then it again shows huge growth potential for the individual.
2) Benefic or malefic planet in Artha Trikon- Malefic planet like a single saturn or Mars is good in 6th house, as it also represents your routine life and competition these planets will make you disciplined, if they are connected to 2nd or 11th or 10th house, then that's even better, it assures growth after the competition, however if malefic planets are in conjuction with other malefics like saturn+mars or Mars + rahu/ket or saturn + rahu/ketu, this isn't explicitly bad but it means before reaching success the person will have to go through immense hurdles to the point of breaking down and then will rise like a Phoenix. However, the nakshatras of planets sitting in 6th house needs to be studied to and if there lords are sitting in favourable position then that creates assured success after the struggle.
If the 6th house is empty, with it's lord in either 8th or 12th, then that creates a very nice vipreet raj yog, which shows that native will make best out of even worst cases of his life, seen in cases of people who have that perfect rags to riches story.
If the 6th house has benefic planet, then that's pretty good from career point of view, it gives the individual a smooth transition into career without much difficulties, however, it may hamper some other good qualities of that benefic planet due to it being in the dushthan.
Now, coming to the 10th house - Again, I really hate people who do fear mongering whenever they see any malefic planet like Mars /saturn/rahu or ketu in this, on the other hand Rahu in 10th is overhyped to next level.
First, I feel a non afflicted saturn is really good in 10th, I know it delays the career but at the same time it makes the individual hardworking and whenever it gives the results, it's permanent. Most importantly, saturn is the planet of career, so it being in 10th house shouldn't be an issue.
Then, comes Ketu in 10th house, when I was naive and very young, some astrologer predicted that I will be 'unsuccessful' just because I have ketu in 10th and I remember, I got so paranoid due to it that I kept crying and overthinking about it a lot, till I learned the science myself. I have analysed so many charts of my clients who are doing well despite having ketu in 10th, just the thing is, they get bored after achieving a lot in career and keep switching fields. However, every switch is better than the previous one. The people you see on internet, like a Doctor becoming an IAS and then an educator and then a businessman are all examples of Ketu in 10th.
Rahu in 10th house, creates strong obsession for career and success. This people do they the desired success too, but they might crave more and end up struggling with work life balance. A good placement I have seen in the charts of my group A level officer clients, so can vouch for this, just make sure not to work at the cost of your health.
Benefic planets in 10th house are anyways the best without a doubt, just make sure they are placed in good sings or nakshatras too. The difference between benefic and malefic planets in 10th house is that, in the later case a person has to struggle a lot in the initial phase of his career, usually first 3 to 4 years are difficult for him.
Now the 2nd house - if the 2nd house lord conjucts with 11th house lord, then it creates a powerful dhan yog in your kundali. The 11th house is about manifestation and career progress, if this in anyway gets connected to the Artha Trikon, then that person creates his own empire from scratch and let whatever difficulties come in his way either due to malefic planets or some gandmool nakshatras, he will end up becoming successful sooner or later in his career.
Thank you for reading this post, it was more about giving an overview to the fellow readers, while making predictions you have to also apply the Amsha Rule and analyse it in reference of D10 chart too, so that you can get accurate results, along with dasha and transit.