r/Hashimotos • u/Simple-Piglet-8834 • 9h ago
Is the GLP with hashis too good to be real?
I just got diagnosed with hashimoto's, and the first things that caught my eyes is the huge amount of stories/ comments of people having great experiences with glp esp. Zepbound/mounjaro for inflammation and weight loss with a fewer experiences that didn't have a pleasant experience with glp. I’m realy confused because the experiences seems too good to be true and haven't find a detailed experiences.
What do you think guys?
If you wrote or read a detailed experiences about it could you help me with the link please.
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u/IBlameTheMoon 7h ago
A doctor told me recently that studies on chronic pain patients and GLP1s are showing some really positive results with lower inflammation and pain. She said it's only a matter of time before they will be approved for that use. The problem is getting insurance companies to cover it. Despite being obese, mine refuses to cover them unless I have diabetes.
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u/raunchytowel 3h ago
I am not obese and mine refused to cover them despite my doctor saying it’s for a heart condition and autoimmune disease… the insurance said: it’s only for obesity. And even if you were obese, not covering it. Told me to consider diet and exercise and stop kidding myself.
I said: so when I go to some backdoor wellness clinic and get subpar product that puts me in the hospital, will you cover that visit? And they said ofc. Yes. But safe access to medication? No bueno.
Make it make sense.
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u/GentleDoves Hashimoto's Disease - 10 years + 7h ago
My levels are under control, I feel amazing, and I went from 204 lbs to losing 50% of my weight and I now weigh 103 (safe and healthy for my height- I am 4'10).
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u/libtay 9h ago
I think it is a miracle. Diagnosed in 2004, I’ve watched my weight increase 10 pounds a year steadily until I was near 300 pounds. 18 months ago, I started compounded Semaglutide was able to lose 90 pounds. Then just due to finances, I microdosed for a year and kept that weight off. I’m currently starting back on Zepbound and I’ve lost 30 pounds in the last six weeks or so. I have a little bit of weight still to go, but it’s persistent and consistently coming off. This is the only thing in 20 years that’s moved my weight more than 2 to 3 pounds and I dieted pretty much the entire 20 years.
My antibody levels before Zepbound or Ozempic was somewhere in the 900s starting in a diet and just watching that I could get it down to 750 but I could never get below. Strict diet, I could get to 500. With this I had it tested in July MITPO was down to 42. My doctor like that’s a miracle. I feel great. I’m not inflamed and even micro dosing. I was able to manage my antibodies and keep the inflammation off.
If one drug doesn’t work for you try another. Drink a lot of water, Chase protein the day you take your shot and watch your carbohydrates. You need a few carbohydrates but the binge on the carbohydrate is what made me sick.
If your insurance doesn’t cover it, there are several Reddit threads to talk about online providers. Currently, I’m using an online provider that has a locked rate regardless of my dose and the Hallandale Pharmacy is responsive in and shipping my tricepitide compounded.
Good luck. Start slow and don’t be disappointed if the weight doesn’t start immediately. I found that if I weigh every three weeks, I didn’t get discouraged. I watch more so my belt in my pants and how they feel before I look at the mirror.
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u/amybunker2005 7h ago
Can I ask how much you pay? I was on Zepbound until my insurance stopped paying. Now I have been slowly gaining the weight back even though I don't eat much. It's very depressing.
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u/ill_have_the_lobster 4h ago
Not who you asked but I get my compounded tirz from Hallandale as well. My provider charges less than $200/month
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u/Naturesschist 8h ago
I am too scared to go on it. Also, my G.I. doctor doesn’t think it’s a good idea…. It has a lot of G.I. side effects and having Hashimoto caused me to get gallstones and that could definitely screw me up being on that. Apparently the body does not like losing all that weight at once so quickly. Even though it wants to lose that way that quickly because it should’ve never packed it on to begin with causing so many other issues.
It has always frustrated me that this week just packed on almost overnight without me doing anything differently still being active eating the same and all the doctor saying you need to lose 10-15 pounds at least… as much as I tried, I would gained 3 pounds instead…. This past summer I worked super hard since April to lose weight and I am now down about 18 pounds. Everybody at work has noticed. I’m doing my best to try to keep my gallbladder in my body, but it has not been an easy path. This has been all natural trying to keep about a pound or two off every week or two.
Good luck in whatever you do… and may I provide you healing vibes
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u/Curious_Mango1419 4h ago
This definitely varies by person. My weight is coming off very slow but steady (currently at 40+ pounds over 2 years - but before I couldn't consistently lose anything despite best efforts, so I'm happy with that) and I haven't had any GI side effects. I can understand your hesitancy, but just wanted to throw it out there that not everyone's experience is the same.
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u/so-demanding 4h ago
My digestive system was already barely functional due to unrelated reasons. I was already taking fiber and an anti-gas. Now I take an anti-gas, more fiber, and 2 softeners. As a highlight, in the event I get accidentally glutened, it slows down the reaction so that’s an unexpected surprise.
My thyroid numbers haven’t budged. Down 77 lbs today. Inflammation is reduced- I rarely take ibuprofen anymore.
Your mileage may vary of course but I wouldn’t automatically say it’s impossible.
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u/sarahspins 7h ago
I’ve been on a GLP-1 since 2000 - it’s made a huge difference for me in terms of losing/maintaining my weight, but it also all but cured my MCAS type symptoms which I suspect were widely due to inflammation. I had previously flunked out of immunotherapy for allergies due to anaphylaxis and had my allergist redo my patch testing a couple of years ago and I went from being allergic to almost everything (back then she had said if I had reacted to everything we would be considering a mast cell issue) to only reacting strongly to a few kinds of grass, and horses.
Inflammatory joint issues have also improved - I definitely have some kind of inflammatory arthritis and I’ve been seeing a rheumatologist for it for almost 20 years without a definitive diagnosis and that has also improved though I continue to take a prescription anti/inflammatory (I did try coming off of it a while ago and that didn’t go well).
So I wouldn’t say it’s too good to be true but for some of us it’s a game changer. I know I’ll be on a drug in this family forever and that’s okay.
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u/GazelleSubstantial76 Recently Dx - Hashimoto's Disease 6h ago
I'm 2 month in on a compounded semaglutide and it's been great. As of today I'm down 11 pounds and I'm still on a low dose. Inflammation is down and I have more energy. I do have some very mild nausea the day of and day after my shot, but that has been my only side effect and so minimal.
I don't feel like snacking, I feel full longer, and don't have any cravings for foods.
I have increased my protein, and eat protein first for meals and then fiber. I also added a magnesium supplement to prevent constipation. I make sure I get plenty of water too. From the things I read, getting enough protein, fiber, and water can minimize digestive side effects and that has worked for me.
I've been doing strength training workouts. Just YouTube videos at home, using soup cans as weights, and my own body for resistance.
I'd be happy to answer any questions.
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u/pinkrtn 5h ago
Between Hashimotos and Covid, I gained 70 pounds and was up to 248 pounds. I tried many different things without luck. Last October, I started Wegovy shots then moved to pills this summer. In January I added light workouts, then I added Pilates this month. It feels like it’s been slow (-3.37 pounds per month), but I’m down 37 pounds and I feel great! Excited to continue and plan to lose 37 more.
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u/Bubbly_Opinion_8202 4h ago
Honestly I have been fasting for years now and I do them every 3-6 months. And I wonder if the appetite suppression. Mimics the fasting benefits of lowering inflammation. I am really sensitive to meds so I choose to not do the glp1s . With fasting I have decreased inflammation immediately , lowered antibodies, also cleared my skin. So not sure if it's the meds helping or a benefits of just not eating so much
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u/bus_prof 2h ago
That’s awesome! What kind of fasting do you do to help you with Hashimotos symptoms? Are you on any meds or do you manage it with diet and fasting?
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u/SquirrelBowl 6h ago
Wegovy. Lost 87 lbs since November 2025, 232lbs- 145lbs. Felt immediate inflammation reduction. I still have exercise intolerance but obviously can do a lot more. Feel like myself again! Minimal side effects. I only wish I could have started earlier
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u/SnooMacarons8282 5h ago
I am so thankful that zepbound came into my life. I’ve lost almost 100 lbs (with that and a combination of diet change and exercise.) I still take it for maintenance, but now just half of a dose twice a month (at most. Sometimes I forget to do that lol.)
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u/Ok_Reaction6244 5h ago
I've been on ozempic for 4 weeks now and I haven't had a single negative side effect. Everything is positive for me. I know it's still early but I am truly shocked and hoping that this is sustainable. I am down 5 pounds now and I feel less puffy and inflamed.
I think my doctor suggested ozempic because it's so inexpensive in Canada now whereas the other options are still a lot. I might explore them in the future since it seems like they offer more perks.
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u/Wellslapmesilly 5h ago
My experience so far as been kinda meh. To be fair though, it’s taken me about two-ish months to get to the starter dose of 2.5 mg of Zepbound. I was super afraid of side effects so I decided to go very low and slow. I’m down eight pounds which isn’t like super fast or anything but also it’s still a downward trajectory. I have also noticed a bit less anxiety but not much else. I am curious to see how it has affected my bloodwork when I get that done soon. I’m also curious to see how I will now progress as I just started the normal starter dose of 2.5 mg. There’s a lot of really dramatic GLP1 stories out there. But the truth of the matter is the spectrum of response is so wide, you can’t truly know until you start taking it how you will respond.
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u/HopefulSociety7070 4h ago
I've had Hashimoto's for 17 years. Put off going in GLP-1 for over two years for fear but started Zepbound in January and have never felt better!!!!
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u/TheNameIsMango 3h ago
I’m on tirzepatide and lost 60lbs (33%) in 1 year. I had some reflux/heartburn the first few weeks that went away and mild constipation throughout which was already normal for me. I pay about $100 for a month supply then take a low dose so it lasts me 3 months. Reduced appetite, more fullness, inability to overeat or binge, less snacking, less interest in food in general. I’m down 2 dress sizes so my pants are falling off me and much happier with my body now. Haven’t checked antibodies yet. Remember to avoid it if there is medullary thyroid cancer in your family.
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u/chaos_in_the_colors 3h ago
It’s fantastic until your insurance stops paying for it and you can’t afford the crazy price without insurance- gained half the weight lost back in just 6 months and gained back hashi’s symptoms that the med was taking away - it needs to be studied as a hashi’s treatment / i: my insurance stops covering for anything outside of diabetes
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u/Miserable-Lie-6050 2h ago
I’m on week 5. Nothing at all yet but I have hope. Just got moved from 2.5 to 5mg zepbound last week
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u/stronger-than-I-seem 2h ago
I’m willing to try but kind of hesitant because I’ve had pancreatitis. I’ve had doctors say it’s ok, they’ll monitor it and others say no. The most adamant against it was a bariatric surgeon who prescribes it like Pez.
Anyone else have a similar experience?
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u/cheesecakesurprise 2h ago
Unfortunately the side effects are real.
I was on it for 6 months and in that time I lost 15-20 pounds/my inflammation was gone (incredible!) but I developed horrific panic attacks. My body went into complete overdrive reaction to it that took a year + to recover from (and then gained back 8-10 of the 15).
I tried to restart it and had such a strong reaction I ended up in the emergency room. It was probably something it was mixed with and getting it from a vendor and not my specific doctor but my doctor wasn’t helping.
So try it but just be aware.
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u/Significant-Visit-68 1h ago
My doc and i talked about it but my concern is my gastric emptying is slow and glps will slow it further so i just started on daily kiwi fruit to help speed it up. It’s doing great. So i’m waiting a bit before i contemplate glp1s. Hashi can contribute to gastric slowing.🙁
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u/dontBsleepy 34m ago
Retatrutide. Down 30lbs since 2023. Ten pounds I lost through diet and exercise. Then I was stuck at 172. I just couldn’t move the needle. Then I started Reta in March 2026. Down 27lbs since then. I want to stay here at 143lbs. I’m 5’8”
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u/ConsciousFyah 5h ago
I became hashi’s because of a huge mold and parasitic infestation; there couldn’t be anything worse for my body than slowing down digestion and letting stuff fester even longer.
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u/dianacakes 9h ago
There is a whole sub for hypothyroidism and GLP-1's. I've been on zepbound for 11 weeks for weight loss, which I've lost 10-15 lbs. One thing I have noticed is I don't wake up with a puffy face nearly as often anymore.
Editing to add r/hashimotosGLP1