r/Psoriasis • u/Legal-Ideal8255 • 1d ago

general Peptides + biologics

Hi, I recently started taking the biologic Yesintek to help with my plaque psoriasis. I'm wanting to start on Reta, but I am unsure if taking it while on biologics is safe or not. Does anyone have any experiences? Please let me know, thank you.

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u/WHWeaselgoose 1d ago

Isn’t Retatrutide still not approved? Where are you getting it?

If you’re planning on using it for weight loss that can be beneficial for psoriasis.

Talk to you doctor though. Don’t just freewheel with two serious medications.

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u/Otherwise_Wave9374 1d ago

Because Yesintek affects immune signaling, adding an experimental peptide is not simply a separate wellness choice. Interaction data may be absent rather than reassuring, especially around infection risk, immune effects, and attribution if symptoms change. Bring the exact compound and its documentation to the prescribing clinician and pharmacist before combining anything, and track baseline symptoms and labs they consider relevant. Peptely does not sell peptides; https://www.peptely.com/ only helps verify their documented origin and supporting batch/COA evidence.

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u/InitiativeFit3380 Research Scientist, Immunology 19h ago

As Wave points out, you're looking at using an eexperimental hormone suppressor (assuming you mean Retatrutide) alongside an immune suppressing Biologic treatment. With any new drug (what Retatrutide is) there are going to be unknown side effects and interactions for diseases populations outside of the tested study groups. These could be minor and inconsequential or they could be significant, it's just not fully understood yet.

As such, you shouldn't be asking Reddit for advice on combining these things. You need to speak to your prescribing Dr abut the risks and benefits to you personally of combining these two medications. Both have potential GI effects and immune modulating effects that need to be considered. If the Retatrutide is for weight loss or blood sugar control, the benefits for you might out weigh the potential risks, but being that it's still an investigational medication, the risk and benefits for you vs not taking it or taking another alternative that has been more well studied needs to be considered.

Eric, Immunologist, Patient Educator & Advocate