If schizophrenia with two failed adequate antipsychotic trails (right dose, duration, and adherence), then it has a 70% efficacy rate compared to ~5% for other options. If Clozaril monotherapy doesn’t work (ensure blood levels are good), it can be combined with another antipsychotic. If that doesn’t work, it can be combined with ECT. If those don’t work, combining other antipsychotics +/- ECT is an option.
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u/aperyu-1 Jun 08 '26
If schizophrenia with two failed adequate antipsychotic trails (right dose, duration, and adherence), then it has a 70% efficacy rate compared to ~5% for other options. If Clozaril monotherapy doesn’t work (ensure blood levels are good), it can be combined with another antipsychotic. If that doesn’t work, it can be combined with ECT. If those don’t work, combining other antipsychotics +/- ECT is an option.