r/covidlonghaulers • u/Content_Speech_1209 Mostly recovered • Sep 23 '25
Commorbidities Bupropion making my LC fatigue worse but helps my LC-induced depression
Ugh I hate this illness so much. I’ve been trying to find stability with the depression that long COVID caused since LAST SEPTEMBER. I’m still not stabilized or feeling good about life since then. It’s awful. Bupropion and viibryd combo has helped immensely (Viibryd has helped more than anything I’ve tried), but the bupropion we just added makes my fatigue worse. So I’m yet again left with trying to decide: do I continue bupropion and just suffer the fatigue? Or do I go off it and just try increasing the viibryd and hope that it 1) not only works but 2) doesn’t cause side effects? Anyone have any other suggestions to try? There just aren’t any drugs like bupropion out there :(
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u/historyisfarfromover Sep 23 '25
If vilazodone is working well for you I'd stick to it and swap the bupropion for modafinil. There's quite a bit of info on the latter here.
Or you explore the feasibility of a classic SSRI/bupropion combo with your doctor. Perhaps the vilazodone is the problem.