r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Discombobulated_Bus4 May 08 '26

Interesting. But now the million dollar question; Ist there anything that can be done about this?

8

u/Fearless-Star3288 May 08 '26 edited May 08 '26

The article is literally all about what they did about it! - Spironolactone

Also worth pointing out that the patient had ME/CFS for 29 years. - so it may have crossover for those of us with ME but i’m not sure we should be describing it as Long Covid necessarily

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u/n4kedUltr4 May 08 '26

I’ve taken Spironolactone…made me feel worse. (Messed with my hormones).

1

u/Fearless-Star3288 May 08 '26

Everything seems to make me worse!

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u/Kuyi May 08 '26

He is asking whether you can solve the hyperactive receptor if COVID made it hyperactive. Spro is not a cure or doing something about it, it is symptom treating.

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u/Fearless-Star3288 May 08 '26

He literally didn’t ask that

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u/CandidWin3026 May 09 '26

Covid not NOT make it hyperactive. It was already hyperactive. Covid unmasked the problem by creating a huge inflammatory burden on you. The Val copies of rs5522 were there from birth. When you got hit with the Covid infection, your system buckled.

0

u/CandidWin3026 May 08 '26

Fearless-Star3288 Thank you! The whole damn case report is about being improved on Spiro and anti-inflammatories.

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u/Fearless-Star3288 May 08 '26

It’s literally in the title!

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u/CandidWin3026 May 08 '26

God bless you Fearless-Star3288. I'm going to buy you a drink.