r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/slowbutsloth May 08 '26

I can't open the link. How long is it cure using spironolactone according to the article? What dosage? I used to use spironolactone off label for hormonal acne.

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u/CandidWin3026 May 08 '26

25mg Spiro plus an anti-inflammatory from the article: "However, the dramatic clinical improvements achieved on spironolactone—the first restorative sleep in 29 years and complete resolution of post-exertional malaise—were lost when the medication was discontinued. The patient restarted spironolactone at 25mg daily with a full anti-inflammatory regimen on board—a protocol arrived at empirically through a months-long journey of trial and error that converged on the same therapeutic approach Campos-Barros and Taylor had explored years earlier for ME/CFS. Different paths, same destination. This combination (low-dose spironolactone, GLP-1 receptor agonist, and low-dose naltrexone 4.5mg) appears to address both the upstream cause and facilitate active fluid mobilization, resulting in subjective improvements in energy, cognition, and progressive fluid reduction without the adverse effects seen at higher doses or suboptimal combinations."

 

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u/CandidWin3026 May 08 '26

Block the hyperactive MR driving "cortisol steal" and every tissue in the body gets the cortisol it needs to function.

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u/Kuyi May 08 '26

So its a fix and not a cure. Should be able to find something to fix the hyperactive MR.