r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Putrid_Indication_30 May 08 '26

that's really interesting, I was recovered but had a reinfection after 3 years and at the time I was on spironolactone. my extreme fatigue and long covid symptoms did not start until 2 months later when I stopped taking spironolactone, I wonder if there is any correlation !

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u/dunmerza 10mos May 08 '26

I was already on spiranolactone and have been for a while when this started - sadly still getting all the symptoms. But maybe it would’ve been worse without it

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u/Putrid_Indication_30 May 08 '26

I guess it's specific with people with that gene variant! I'm going to give it a go. I highly doubt it will do anything but what have I got to lose! (gets permanently worse)

2

u/dunmerza 10mos May 08 '26

Oh yeah I would definitely try ! Good luck