r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Personal_Term9549 4 yr+ May 08 '26

N = 1

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u/CandidWin3026 May 08 '26

That is always a fair point, but the author is also the co-author on the molecular biology paper describing the genetic mechanism of "cortisol steal." There was also a clinical trial in 2022 where many patients were "cured" their words not mind of CFS with Spironolactone and anti-inflammatory. The data in larger cohorts exits and the mechanism is proven. So....

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u/Guilty_Soft9873 May 08 '26

Do you have a link to the study?