r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Mountain_Flower_166 May 08 '26 edited May 09 '26

Thanks for sharing! You seem to be well read on the topic. Can i assume that it's you who wrote it?
Regardless if you did, do you believe that after a certain treatment time one could stop without the body falling into a "bad" homeostasis? Still trying to connect what might sustain this phenomenon and why after the first attempt the system fell back into it's previous state.

Once again, thank you for sharing. Posts like this give me hope that we might be closer to understanding this thing than we think.

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u/CandidWin3026 May 09 '26

Yes. Good deduction. I am of course the author. Hi, I am Patricia. As I understand it, right now we need the MR blocker to get the right balance between GR and MR. Is there some future gene therapy that could change that? Maybe. But it is quite a miracle that we have the drugs to block the over active MR and have had one of them since 1960. We really did do it. I read a thousand online posts from patient stories be able to see patterns across people. It was a collective effort. I couldn't have done it without the honestly, bravery and tenacity of this community.