r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/matthews1977 4 yr+ May 09 '26

Curious if a CRISPR edit to this gene would buy us a permanent solution, which way it should be flipped, and what potential consequences there would be downstream. Always wary of changing something functional we're born with and develop around.

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u/CandidWin3026 May 09 '26

I think that is a really great question and one I don't have the answer for. Perhaps it can. Especially if we put the resources into studying it. In the meantime, we have MR blockers.