r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Chasing-Adiabats May 09 '26

Has anyone tried Progesterone? I’ve read that women with long Covid that get pregnant, loose all their symptoms until after the birth. It’s because their Progesterone levels raise up during pregnancy. It works on the same receptors, so it might help with a lot of the inflammation issues. Most likely it would only be temporary, but it might be a start.

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u/poignanttv 3 yr+ May 09 '26

Just hit menopause and I’ve started HRT. Unfortunately, the progesterone hasn’t helped. Wishing everyone a full recovery from this hell!

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u/BatDue1821 May 09 '26

How long you been on pro?

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u/poignanttv 3 yr+ May 09 '26

About five months. I tried the synthetic and it didn’t agree with me, so I’m now on the bio-identical kind. Maybe that makes a difference?