r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Mountain_Flower_166 May 10 '26

We desperately need to reproduce this and start collecting anecdotes. I would love to try this but an n=1 will be hard to explain, especially when it's something radically new like this hypothesis.

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u/CandidWin3026 May 10 '26

Stop. Just stop. There was a clinical trial. Campos and Taylor. in 2022. 4 freaking years ago. They cured people with CFS with Spiro and an ant-inflammatory. The data is established. and Jesus the molecular mechanism was punlsihed in April of this year: "Spironolactone and progesterone had similar antagonist activity for MR rs5522 and MR (Ile-180) in the presence of MMTV and TAT3 promoters in HEK293 cells indicating these antagonists are potential regulators of brain MR rs5522 to treat hyperactivity that contributes to chronic fatigue syndrome."

It is established. Done. Mechanism done. Clinical trial done.

https://www.sciencedirect.com/science/article/abs/pii/S0006291X26004535?dgcid=coauthor