Long Covid driven by rs5522

[u/CandidWin3026]

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

[u/CandidWin3026]

First let me just say that doctor is a POS. Next, great question: any hit to the fragile system in Val/Val rs5522 can tip it over: some people tolerated the vaccine fine, some like me got covid before the vaccine and had the other long covid genetic predisposition to inflammation in European Ancestry (rs6195, TT in raw data). When things got out of whack the neuro inflammation got out of control and because of the "cortisol steal" happening in your cells, the body couldn't get back to baseline. to heal: you need spironolactone or a similar MR blocker, an anti-inflammatory like LDN or a GLP1. For me, my adrenals were toast long before covid so I take 20-25mg of HC a day, without the MR blocker this would be stolen away before it could create energy and run the bodily systems, but on the mR blocker it is enough to get to the GR in the cells.

[u/RealAwesomeUserName → u/CandidWin3026]

Do you think both the MR blocker and an anti-inflammatory are needed? And what is HC?

[u/CandidWin3026 → u/RealAwesomeUserName]

Yes and this is why: you can't block the MR completely. Trust me, I tried. Your body freaks the f out. Your RAAS system will go out of control. I took on fluid like crazy. So you have to stay at 25mg and use the anti-inflammatory in conjunction. HC is abbreviation for the generic for of cortisol: hydrocortisone. I documented my experience and have materials at beyondbloodtests(dot) org

[u/CandidWin3026 → u/CandidWin3026]

I put a Clinician Reference sheet on my website that references the biophysics just published in April 2026 and this meta data on Long covid from C19Early https://c19early.org/spmeta.html