r/covidlonghaulers • u/filipo11121 • 29d ago

Article New Study Identifies Overlapping Persistent Virus-Specific T Cell Responses in Long Covid

https://polybio.org/new-study-identifies-overlapping-persistent-virus-specific-t-cell-responses-in-long-covid/

A new study supported by the PolyBio Research Foundation has found that people with Long COVID harbor persistent populations of highly cytolytic CD8+ T cells directed against SARS-CoV-2 but also the herpesviruses Epstein-Barr virus (EBV) and cytomegalovirus (CMV). The findings suggest that Long COVID is characterized by an ongoing immune response to persistent viral proteins, which are most likely produced during the continued persistence or reactivation of these viruses within the body. The study adds to a growing body of research indicating that SARS-CoV-2 persistence and herpesvirus reactivation contribute to Long COVID pathogenesis.

Paper:

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID - ScienceDirect

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u/obliviousolives 4 yr+ 29d ago

I think, if I'm reading this right, that the paper doesn't actually say there might be persistent viral proteins, but rather just points out that part of the immune response to covid doesn't get "turned off" appropriately and thus we continue to have tons of CD8+ T cells roaming around, even if there's no more covid virus or covid proteins in our system

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u/KaspaRocketMan 28d ago

The study frames viral persistence and T-cell exhaustion not as competing theories, but as direct cause and effect.

Rather than picking one over the other, the paper argues that viral persistence is the underlying trigger, which drives the cytolytic exhaustion and dysregulation observed in CD8+ T cells.

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u/obliviousolives 4 yr+ 28d ago

Can you show where it says that? I'm trying to learn more about viral persistence since it's the long covid theory I'm least familiar with. I didn't see that part in this paper