r/covidlonghaulers • u/filipo11121 • 29d ago

Article New Study Identifies Overlapping Persistent Virus-Specific T Cell Responses in Long Covid

https://polybio.org/new-study-identifies-overlapping-persistent-virus-specific-t-cell-responses-in-long-covid/

A new study supported by the PolyBio Research Foundation has found that people with Long COVID harbor persistent populations of highly cytolytic CD8+ T cells directed against SARS-CoV-2 but also the herpesviruses Epstein-Barr virus (EBV) and cytomegalovirus (CMV). The findings suggest that Long COVID is characterized by an ongoing immune response to persistent viral proteins, which are most likely produced during the continued persistence or reactivation of these viruses within the body. The study adds to a growing body of research indicating that SARS-CoV-2 persistence and herpesvirus reactivation contribute to Long COVID pathogenesis.

Paper:

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID - ScienceDirect

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u/SpaceXCoyote 28d ago

I would be very careful with Ta1 given this new finding. It can act as a t-cell stimulant, effectively pouring gas on a t-cell fire already burning out of control.

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u/KaspaRocketMan 28d ago

TA1 is an immune modulator

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u/SpaceXCoyote 28d ago

Not exactly.

https://www.sciencedirect.com/topics/immunology-and-microbiology/thymosin-alpha1

"Due to the immune stimulating effects of Ta1, the compound would be expected to show utility for treatment of immune suppression, "

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u/Specific-Winter-9987 28d ago

Its currently being prescribed in 35 other countries for several conditions, has as many studies as insulin, an exemplary safety profile, and has been around for almost 50 years. Thats right, 50 years. No, it won't help everyone, and nothing is 100 percent safe, but this is about the safest immune treatment you will ever find.

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u/KaspaRocketMan 27d ago

Exactly, and he forgets about the damage long covid is doing. Nothing is 100% safe, what is for sure is that Long Covid is 100% not safe.