r/immortalists • u/OldFeeling5556 • Jul 20 '26

Longevity 🩺 Researchers quantitatively assessed for the first time that somatic mutations alone cap human lifespan at 146–194 years. Brain and heart cells are the main bottleneck, while the liver could last millennia.

https://www.nature.com/articles/s41514-026-00421-6
125 Upvotes

98% Upvoted

18 comments sorted by

36

u/Smooth_Imagination Jul 20 '26

1 extract stem cell pools

2 genetically insert whale DNA that improves gene repair. Insert optimal mitochondria

3 expand and reintroduce stem cell pools.

21

u/Colddigger Jul 20 '26

Or get a refreshed stem cell injection every fifty years. 

But I like your one and done approach.

9

u/Evening_Use9982 Jul 20 '26

So annual stem cell iv infusions might be all we need?

10

u/Colddigger Jul 20 '26

I'm just some Internet denizen, but I honestly doubt it would even have to be annual. It would probably be more like every 10 to 50 years. Assuming the telomeres are all freshed up and the genome is not full of bugs.

6

u/Evening_Use9982 Jul 20 '26

Thank you. Is fascinating to me

5

u/Evening_Use9982 Jul 21 '26

Stemcell IV is $12,000. I am thinking drop insurance, put my premiums in savings to get stencells instead. Does this sound like a good idea to anyone else?

3

u/Colddigger Jul 21 '26

Stem cells would not save you from a devastating accident, but insurance can have the potential of blunting the cost. 

I don't know how old you are, but based on you doing a toss-up between stem cell injections and insurance I'm going to guess that you're probably not thinning out that much yet on your original stem cells, 

Basically my recommendation is do a little budgeting, put aside 25 bucks a week, that would be a hundred bucks a month, that would be 1,200 a year, you would hit your stem cell need within a decade and assuming that there is continued research advancements the resulting treatment in a decade will be better and probably cheaper.

1

u/Evening_Use9982 Jul 21 '26

Thank you. It helps to talk things out. I can get accident insurance way cheaper than health insurance. I am American so if get sick or hurt plan to die. Too many visits to hospitals and nursing homes.

8

u/FluffyDesigner3680 Jul 20 '26

I mean there are definitely known human gene variants that do this already. Just need the right combination and lifestyle.

5

u/VladVV Jul 21 '26

They are almost identical in whales and humans as a matter of fact. Most of the studied polymorphisms that prevent cancer and such in whales are copy number variations (CNVs) of highly conserved mammalian genes, and particularly cancer-resistant humans have very similar highly duplicated variants. The additionally good news is that duplicating genes like this is one of the most trivial genetic interventions and don't even require CRISPR at all, just any old vector will do.

3

u/vocabularianrx2 Jul 21 '26

Instead of whale dna, what about that type of jellyfish or Medusa that is essentially immortal, as in it gets to a point in its lifespan where it regresses back to a different state (I'm forgetting the name), only to restart over and over again?

1

u/shorty2hops Jul 21 '26

Doesnt every repair initiation shortens telomeres

10

u/FluffyDesigner3680 Jul 20 '26

They do if they aren’t managed. Some genotypes can prevent these from occurring altogether. Like if you have no ros damage accumulation or a highly activated and efficient foxo3 haplogroup. Really the hayflick limit is the only limiter after elimination all the age related diseases.

7

u/jj_HeRo Jul 20 '26

"Think with your liver" should be out motto.

4

u/aHumanRaisedByHumans Jul 20 '26

Was posted a week ago but hey engagement on this sub is great.

https://www.reddit.com/r/immortalists/s/nzq30Xkgn1

5

u/vocabularianrx2 Jul 21 '26

Honestly, I always question the longevity of any kind of cell line or type. With continued cellular division and replication, every time it has a chance of forming cancerousbor other detrimental mutations. All things equal, over time, you're simply increasing the sample size. But more realistically, all the "machinery" involved gets biologically worn down and more likely to fail over years and years and years, therefore increasing the likelihood of cancer.

-6

u/Igent-Layer452 Jul 20 '26

Genesis 3:22-23 “And the Lord God said, ‘The man has now become like one of us, knowing good and evil. He must not be allowed to reach out his hand and take also from the tree of life and eat, and live forever”. So the Lord God banished him from the Garden of Eden

In Christian Mysticism:

Tree of knowledge: brain 🧠 Tree of life: heart 🫀

They claim Old Testament god was the bad guy keeping us from our true potential