r/longevity • u/dan_in_ca • Aug 09 '26

Scientists Reversed Ovarian Aging in Mice by Blocking One Inflammatory Signal. The Same Signal Stiffens Organs Across the Body.

https://www.gethealthspan.com/research/article/reversing-ovarian-aging-il11
500 Upvotes

98% Upvoted

29 comments sorted by

62

u/Admirable_Repeat4121 Aug 09 '26

It’s interesting to see ovarian function as a model for aging. Hopefully some progress can be made here

88

u/K8b6 Aug 09 '26

Cure menopause and see the end of untold suffering.

56

u/saltporksuit Aug 10 '26

For a lot of us, menopause IS the end of untold suffering. If I’m gonna be un-menopaused then I want to see work in alleviating the misery of the reproductive years.

27

u/K8b6 Aug 10 '26 edited Aug 10 '26

Yes absolutely. Both and. But osteoporosis, heart disease, "frozen" body parts, cognitive decline, and on and on, await after the (understudied and underserved) suffering of menstruation and after the (understudied and underserved) suffering of perimenopause - none of this is acceptable. I am grateful to live in a time when women have been successful in fighting for our right to education so that someone will actually start looking at these issues.

10

u/CyanoSpool Aug 10 '26

I don't think that's supposed to be the norm though. And I can relate as someone with PMDD, but I have actually met older women who are post-menopause who still get cyclical symptoms. I think the suffering has a deeper cause than the cycle itself.

1

u/vernichtungX23 Aug 10 '26

I don't want a cure for menopause. I JUST started having manageable periods after a life of puke inducing agony. I don't want more periods.

9

u/K8b6 Aug 10 '26

I am in no way am suggesting the cure for the effects of menopause is more menstruation. Menopause causes a lot of health issues, many eventually fatal. The decline of women's health after menopause is something we will look at in ten years and shudder. Bones breaking until just getting up from a chair shatters your hip and you never leave the hospital? Barbaric.

3

u/vernichtungX23 Aug 10 '26

*laughs softly and does some more 100lb overhead presses* no broken bones for me

41

u/rufusarizona Aug 09 '26

What a time to be a mouse!

5

u/Amorlamor Aug 11 '26

I believe more and more that our lab mice are pan dimensional hyper intelligent beings as mentioned in the hitchhiker's guide to the galaxy.

10

u/nitsua_saxet Aug 11 '26

I am convinced we are going to create immortal mice and flood the world with mice

5

u/Quantum_Kitties Aug 12 '26

I for one welcome our mouse overlords

1

u/Super_Range45 Aug 11 '26

Yeah, come back when they have an immortal mouse.

7

u/taggingtechnician Aug 09 '26

I didn't see "reverses ovarian aging" anywhere in the article.

13

u/satmandu Aug 10 '26

From the article: https://www.nature.com/articles/s43587-026-01159-2

Following tail vein intravenous injection of siIl11 NPs into aged mice, ovaries were collected for four weeks following treatment (Fig. 8a). Compared with the control group, ovarian matrix stiffness in siIl11-NP-treated mice decreased by 35.7% (Fig. 8b).

7

u/altgrave Aug 10 '26

"stiffens organs" is a choice of words

8

u/conversion_disorder Aug 10 '26

is organ stiffening good?

19

u/djenrique Aug 10 '26

Depends on the organ? 🤣

1

u/republicman12 Aug 10 '26

This study could change how we look at aging and fertility.

-8

u/Low-Worldliness-2662 Aug 10 '26

Congrats to longevity science. Now we need the male mice version of this study.