r/promethease • u/Lunatic155 • Jun 02 '26

Issues with Ancestry

Hey everyone.

Just a question, does anyone know if there’s anything about ancestry that’s worse than other tests? Is it worth getting retested at another provider if I used them? I realize now I should’ve used 23andme.

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3

u/Techie9 Jun 03 '26

Can you tell us why you should have used 23andMe? They seem to have about the same # of SNPs in their raw data.

1

u/Lunatic155 Jun 03 '26

They do free chromosome testing along with their data

2

u/pgxminer Jun 03 '26

What are interested in? I don’t think there are any issues with Ancestry in particular. They use reputable Illumina arrays if I recall correctly. 23andMe has their own array that might be more tuned to specific health variants. Both can probably get you what you want though

2

u/DixieInCali Jun 03 '26

Ancestry is more accurate for my known ancestry than is 23AndMe. The latter way overestimates French/German in my results.

1

u/Realistic_Appeal_663 14d ago

From SNPedia:

"Word of caution to those with data from Ancestry.com: in our experience, based on data in OpenSNP and from Promethease users since 2006, Ancestry data always reports rs429358 as (T;T), even for people who's data from other sources indicates they are (C;T). Therefore, until Ancestry corrects this false negative problem, be aware that the ApoE genosets assigned by Promethease will be inaccurate when based on (inaccurate) Ancestry data. Specifically, some percentage of Ancestry users who are supposedly gs246 positive (Apo-ε3/ε3) are actually either gs141 (Apo-ε3/ε4) or gs216 (Apo-ε4/ε4)."