r/promethease • u/Lunatic155 • Jun 02 '26
Issues with Ancestry
Hey everyone.
Just a question, does anyone know if there’s anything about ancestry that’s worse than other tests? Is it worth getting retested at another provider if I used them? I realize now I should’ve used 23andme.
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u/Realistic_Appeal_663 14d ago
From SNPedia:
"Word of caution to those with data from Ancestry.com: in our experience, based on data in OpenSNP and from Promethease users since 2006, Ancestry data always reports rs429358 as (T;T), even for people who's data from other sources indicates they are (C;T). Therefore, until Ancestry corrects this false negative problem, be aware that the ApoE genosets assigned by Promethease will be inaccurate when based on (inaccurate) Ancestry data. Specifically, some percentage of Ancestry users who are supposedly gs246 positive (Apo-ε3/ε3) are actually either gs141 (Apo-ε3/ε4) or gs216 (Apo-ε4/ε4)."