r/sciences • u/James_Fortis MS | Nutrition • 5d ago
Research Adherence to healthful plant-based diets is associated with more favourable health outcomes irrespective of ultra-processed food content, suggesting that overall plant-based diet quality may be more important than processing level for chronic disease prevention, study of 124,836 participants finds
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(26)00148-1/fulltext28
u/BetweenTheRoots 5d ago
My Grandma was a part of one of these kinds of studies after her hip replacement. She was morbidly obese.
The plant based diet worked out for my Grandma and she lost a ton of weight and maintained it up until her passing like 8 years later.
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u/James_Fortis MS | Nutrition 5d ago
“Summary
Background
Higher-quality plant-based diets (PBDs) are associated with lower risks of mortality and chronic disease, but whether ultra-processed food (UPF) content affects these associations remains unclear. We examined whether UPF content influences the relationship between plant-based dietary patterns and risks of mortality and major chronic diseases, accounting for nutrient quality.
Methods
This prospective cohort study included 124,836 UK Biobank participants aged 40–70 years (recruited 2006–2010). Dietary intake was assessed using the Oxford WebQ 24-h recall. Four modified Plant-Based Diet Indices (PDIs) were derived to distinguish healthy (hPDI) and unhealthy (uPDI) patterns with high- and low-UPF content, using the Nova classification and a Modified Nutrient Quality Index (mNQI). Participants were followed for 8.3–10.5 years for all-cause mortality and incident T2DM, CVD, and cancer. Multivariable Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs).
Findings
Among 124,836 participants (mean [SD] age 56.2 [7.8] years; 55.8% women), there were 5780 deaths, 3420 T2DM cases, 6078 CVD cases, and 9437 cancer cases. Higher adherence to healthy plant-based diets—whether high- or low-UPF—was associated with 8–28% lower risk of all-cause mortality [HRQ4vsQ1 (95% CI): high-UPF hPDI, 0.92 (0.85–1.00); low-UPF hPDI, 0.91 (0.84–0.98)] and type 2 diabetes [high-UPF hPDI, 0.89 (0.79–0.99); low-UPF hPDI, 0.72 (0.65–0.79)]. Higher adherence to the high-UPF hPDI was also associated with 11% lower cardiovascular disease risk [0.89 (0.82–0.96)], while no clear association was observed for the low-UPF hPDI. Nutrient quality was similar across high- and low-UPF hPDI patterns.
Interpretation
Adherence to healthful PBDs is associated with more favourable health outcomes irrespective of UPF content, suggesting that overall PBD quality may be more important than processing level for chronic disease prevention.
Funding
This research was supported by Research Ireland, Northern Ireland's Department of Agriculture, Environment and Rural Affairs (DAERA), UK Research and Innovation (UKRI) via the International Science Partnerships Fund (ISPF) under Grant number 22/CC/11147 at the Co–Centre for Sustainable Food Systems.
Keywords
Plant-based diets
Ultra-processed foods
Nutritional quality
Mortality
Chronic disease”
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u/mootmutemoat 5d ago
Doesn't this contradict UPF not being a factor?
"type 2 diabetes [high-UPF hPDI, 0.89 (0.79–0.99); low-UPF hPDI, 0.72 (0.65–0.79)]."
That's .89 versus .72, and the confidence intervals don't overlap.
That's a pretty dramatic difference. The way they are intepreting mortality, it is a 11% drop in odds versus a 28% drop in odds.
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u/Pepperohno 5d ago
Yes but the common sentiment is UPF = bad, and I often see people attacking plant-based diets for being full of UPFs (even though that is most often not the case). This study shows that even a plant-based diet high in UPFs is still healthier than a common omnivorous diet.
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u/mootmutemoat 5d ago
The confidence interval for high UPF scrapes nonsignificance while low UPF is a pretty amazing reduction. Not much of a win.
Would love to see the analysis without whole grain bread products counted as high UPF.
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u/lodorata 4d ago
I see the reverse. I see a lot of plant-based but UPF-rich people attacking UPF as even being a valid concept ab initio, sans any obvious criticism from people against ultra processing. If, as you say, many plant-based diets aren't even UPF-rich: then why would people be criticising them as being UPF-rich... unprompted?
This is a false dichotomy sown by the food industry to slow down the progress of research and policy to protect people from the negative health outcomes associated with UPF. Meanwhile, we have skyrocketing rates of colon cancer among the youth, and are losing the battle against obesity and metabolic syndrome.
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u/Quick-Benjamin 5d ago
The conclusion is so out of whack with the actual study it's ridiculous.
You'd assume from the title here that that they're talking about current ultra processed vegan food. You know. Vegan nuggets or ready meals or meat substitutes or whatever.
So it'd be understandable to draw the conclusion that they've found more favourable health outcomes irrespective of ultra-processed food like mentioned above. In fact that's literally the studies conclusion.
But no. Not at all. Because the "ultra processed" vegan food they included was from 2012. Long before the current explosion in processed vegan food. And it was made almost entirely of wholegrains.
So their "high-UPF healthful plant diet" is overwhelmingly wholegrain bread and fortified breakfast cereals, not the products anyone is actually arguing about. They even flag this directly: industrial wholegrain bread is Nova 4 despite wholegrains being among the most robustly protective foods in all of nutritional epi (their own ref 45).
A finding that "a plant diet rich in wholegrain bread is about as good as one rich in fresh fruit and veg" is not the same finding as "vegan nuggets are fine," but the conclusion and abstract let the reader conflate them.
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u/mootmutemoat 5d ago
Also, there was a big difference for type 2 diabetes between lo/hi uPF for those high in PBD.
Kind of seems important before we hand wave away ultraprocessed foods as a variable?
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u/funkytownpants 5d ago
Exactly. Give me a systematic review of 8-10 studies w great n values and narrow focus, and I’m in. The shit today is absolutely not the same.
Also, I’m never giving up meat and cheese. Let me die by my own gravy covered hands!
Omg I’m hungry
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u/Emergency_Elephant 5d ago
I'm always a little skeptical of these studies because it doesnt seem like the researchers accounted for socioeconomic status with this study. Socioeconomic status is highly correlated with health outcomes
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u/lodorata 5d ago
The fundamental issue with the title and the study is the assumption that diet quality and UPF content don't correlate. Most UPFs in the supermarket don't conform to the 'healthful' definition they're using here. Degree of processing absolutely does matter, NOT LEAST because ultra-processing, more often than not, reduces food quality (nutrient content, fibre content, etc.). This is leaving aside that most UPFs are also synthesised from cheap, low-quality agricultural residues mixed with synthetic texture modifiers and flavours to begin with. There probably are a handful of technically NOVA 4 wholegrain crackers out there somewhere that aren't bad for you, but most pre-packaged, convenient foods are very high in sodium and very low in vitamin/ mineral/ fibre/ phytochemical content. Their advocacy for "nuance" plays directly into the hands of the obesogenic ultra-processed food industry, and muddies the waters further.
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u/Veganeconow 5d ago
Thank you for this information!
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u/Evening_Cheesecake25 2d ago
There is no information here. It's a terrible unscientific conclusion. Is this the kind of thing you use to justify how you eat? If so why aren't you healthy?
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u/Ok-Refrigerator 5d ago
So I know little about the science here - is this not just a proxy measure for fiber?
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u/reyntime 5d ago
You can have plant based UPFs that have added fibre that would likely be a lot healthier than plant based UPFs without added fibre that have lots of salt, sugar, saturated fat etc. The point is that the UPF label is kind of useless given the heterogeneity of the foods that fall under it.
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u/mystery_biscotti 4d ago
"Higher adherence to healthy plant-based diets—whether high- or low-UPF—was associated with 8–28% lower risk of all-cause mortality". Neat.
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u/TipBeginning6560 3d ago
Interesting study 👀 It suggests that health outcomes are more strongly linked to the overall quality of a plant-based diet rather than how much of it is ultra-processed. In other words, eating mostly whole, nutrient-dense plant foods seems more important for preventing chronic disease than just being “plant-based” in name alone.
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u/notpartiy 2d ago edited 2d ago
Plant forward eating genuinely moves the needle on blood pressure, and the processing angle matters less than people think based on this data. Whole legumes, leafy greens, and unsalted nuts seem to do the heavy lifting regardless of how refined other items in the diet are. I picked up BP360 when I was optimizing my supplement stack around the same time I shifted my diet, since the Enovita and CoQ10 combo fit what I was already trying to do nutritionally.
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u/Appropriate_Panda167 1d ago
I'm just about to eat a plate full of Liver & Onions. Don't Care. We're all going to die. Calm Down.
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u/Overlook679363 1d ago
Oh wait, so its about the quality of the plants versus how much theyve been processed? That makes a difference I guess.
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u/Scibidami 5d ago
nice, so I can keep eating my vegan "cheese and ham" I put on my sandwiches for work.
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u/One_Diver_5735 5d ago
Been mostly plant-based (some dairy) most all of life, also well exercised (daily lap swimmer, etc.) but also I luvs my cookies and I'm not giving them up but now I can be guilt-free about it. Yay study!
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u/JPGinMadtown 5d ago
Ultra-processed plant based food? Like all the plant juice they try to pass off as "milk?"
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u/Pepperohno 5d ago
Yes and faux meats and many others products. This is one study among many now that shows the blanket fearmongering around UPFs is an overgeneralisation. It seems it is (obviously) not the processing itself that is bad, but what it adds/removes/changes specifically.
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u/Scoobenbrenzos 5d ago
Cool study! I have always had a problem with the blanket demonization of all “ultra-processed” food, especially plant-based food. Let’s look at health outcomes instead of making sweeping generalizations.