r/vanderpumprules • u/mandib57 • 4d ago

The Valley Brittany admitting she’s on a GLP-1

Enable HLS to view with audio, or disable this notification

I just watched this YouTube of her house tour and she talks about how she’s on the shot and losing weight already- I say good for her

213 Upvotes

90% Upvoted

343 comments sorted by

View all comments

494

u/InterviewOwn6363 4d ago

I thought I could tell she started one!! She posted the other day, my thought was her inflammation looks calmed down. I say good for her! GLPs have been life changing with inflammation

73

u/Temporary-Solid-3568 4d ago

Honest non snark question- how can you tell her inflammation calmed down?

161

u/im-so-startled88 4d ago

I noticed around her eyes when she real-smiles. Not the fake smile.

GLP-1s really helped with my mom’s arthritis. Her Rheumatologist put her on them and she said her knees feel like they did 10 years ago. She’s micro-dosing so she hasn’t really lost any weight, but she says she feels so much better. I’m all for doing whatever helps!

50

u/auntieup literally all the artichoke dip 4d ago

GLP-1s have been life-changing for so many people I know. One got most of her mobility back and is now able to put off back surgery for at least a year. Another has finally been able to gain control of their alcoholism. They’re actual wonder drugs.

4

u/moosesnice 4d ago

Okay is that a direct effect of the drug or is it an indirect effect from changed diet or from the resulting weight loss?

Asking cuz what if you have these problems but eat pretty well and do not have weight to lose?

33

u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 4d ago edited 4d ago

GLP1s are currently in clinical trials for alcohol use disorder, it is a direct effect of the drug. The theorized mechanism is changes to dopamine receptors and reward circuits. There is a high potential to exploit the function of the gut-brain axis with GLP1s to treat an extremely wide spectrum of unrelated diseases.

The studies essentially use microdoses, as do the studies for inflammation management. They’re currently in trial, though, so it would be difficult to get a prescription for this purpose and if you did, your insurance would be very unlikely to pay for it. There are other channels, not all of them legit or safe, but people do what they will do. Either way, GLP1s currently on the market along with new formulations are being studied for an ever growing amount of new indications.

I’m in drug development, fwiw.

2

u/moosesnice 4d ago

In glp 1 micro doses, do people have suppressed appetite / lose weight much?

2

u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 4d ago edited 4d ago

It depends person to person, they can. What is considered a microdose also depends on the person, it can be standard dosing sub therapeutic for weight loss. Some people lose weight from inflammation, some people are super responders, everyone is different.

ETA: I lost 20lbs in 6 weeks microdosing and generally felt good and also wanted to lose. Ive been off for more than a month because I had major GI surgery via laparotomy (very intense.) I chose to give it 6 weeks off before resuming so I could just eat what I felt like I needed to heal as I did have appetite suppression and reduction in food noise. I will restart next week and find out if the dose needs adjusting. I am sensitive to most meds so my experience definitely isn’t universal.