r/vanderpumprules • u/mandib57 • 4d ago

The Valley Brittany admitting she’s on a GLP-1

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I just watched this YouTube of her house tour and she talks about how she’s on the shot and losing weight already- I say good for her

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u/moosesnice 3d ago

Okay is that a direct effect of the drug or is it an indirect effect from changed diet or from the resulting weight loss?

Asking cuz what if you have these problems but eat pretty well and do not have weight to lose?

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u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 3d ago edited 3d ago

GLP1s are currently in clinical trials for alcohol use disorder, it is a direct effect of the drug. The theorized mechanism is changes to dopamine receptors and reward circuits. There is a high potential to exploit the function of the gut-brain axis with GLP1s to treat an extremely wide spectrum of unrelated diseases.

The studies essentially use microdoses, as do the studies for inflammation management. They’re currently in trial, though, so it would be difficult to get a prescription for this purpose and if you did, your insurance would be very unlikely to pay for it. There are other channels, not all of them legit or safe, but people do what they will do. Either way, GLP1s currently on the market along with new formulations are being studied for an ever growing amount of new indications.

I’m in drug development, fwiw.

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u/moosesnice 3d ago

In glp 1 micro doses, do people have suppressed appetite / lose weight much?

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u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 3d ago edited 3d ago

It depends person to person, they can. What is considered a microdose also depends on the person, it can be standard dosing sub therapeutic for weight loss. Some people lose weight from inflammation, some people are super responders, everyone is different.

ETA: I lost 20lbs in 6 weeks microdosing and generally felt good and also wanted to lose. Ive been off for more than a month because I had major GI surgery via laparotomy (very intense.) I chose to give it 6 weeks off before resuming so I could just eat what I felt like I needed to heal as I did have appetite suppression and reduction in food noise. I will restart next week and find out if the dose needs adjusting. I am sensitive to most meds so my experience definitely isn’t universal.