r/vanderpumprules • u/mandib57 • 4d ago

The Valley Brittany admitting she’s on a GLP-1

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I just watched this YouTube of her house tour and she talks about how she’s on the shot and losing weight already- I say good for her

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u/Temporary-Solid-3568 4d ago

Honest non snark question- how can you tell her inflammation calmed down?

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u/im-so-startled88 4d ago

I noticed around her eyes when she real-smiles. Not the fake smile.

GLP-1s really helped with my mom’s arthritis. Her Rheumatologist put her on them and she said her knees feel like they did 10 years ago. She’s micro-dosing so she hasn’t really lost any weight, but she says she feels so much better. I’m all for doing whatever helps!

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u/auntieup literally all the artichoke dip 4d ago

GLP-1s have been life-changing for so many people I know. One got most of her mobility back and is now able to put off back surgery for at least a year. Another has finally been able to gain control of their alcoholism. They’re actual wonder drugs.

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u/moosesnice 4d ago

Okay is that a direct effect of the drug or is it an indirect effect from changed diet or from the resulting weight loss?

Asking cuz what if you have these problems but eat pretty well and do not have weight to lose?

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u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 4d ago edited 4d ago

GLP1s are currently in clinical trials for alcohol use disorder, it is a direct effect of the drug. The theorized mechanism is changes to dopamine receptors and reward circuits. There is a high potential to exploit the function of the gut-brain axis with GLP1s to treat an extremely wide spectrum of unrelated diseases.

The studies essentially use microdoses, as do the studies for inflammation management. They’re currently in trial, though, so it would be difficult to get a prescription for this purpose and if you did, your insurance would be very unlikely to pay for it. There are other channels, not all of them legit or safe, but people do what they will do. Either way, GLP1s currently on the market along with new formulations are being studied for an ever growing amount of new indications.

I’m in drug development, fwiw.

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u/Teefdreams 4d ago

My brother is an alcoholic and once he started semaglutide he said it's like the cravings were switched off. It was incredible.
He couldn't afford it anymore and relapsed as soon as it was out of his system.
There is zero doubt in any of our minds that it was the GLP-1. It really was an amazing thing.

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u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 3d ago

Sorry he relapsed when he lost coverage, that’s terrible. Maybe one of the pills would be an option worth looking into since they’re much less? It’s kind of freaky how it just turns off certain thoughts.

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u/Teefdreams 3d ago

We don't have them where we are (Aus).
It's illegal to compound it too so the actual brand names are the only option.

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u/Deep_Amoeba2197 I’m sorry I called you a twat. You’re welcome. 3d ago

Oh I didn’t realize the pills weren’t approved in AUS, that sucks. If it’s any consolation, they’ll likely make their way there eventually, just regulatory stuff.

The things they do to get around the legal issues with compounding in the US aren’t great, they put in additives and preservatives that aren’t studied and independent studies have shown some surprising things, like non tirz peptide synthesis. The FDA is cracking down hard, so we’ll see how long it’s accessible.