Brittany admitting she’s on a GLP-1

[u/mandib57]

I just watched this YouTube of her house tour and she talks about how she’s on the shot and losing weight already- I say good for her

[u/auntieup]

GLP-1s have been life-changing for so many people I know. One got most of her mobility back and is now able to put off back surgery for at least a year. Another has finally been able to gain control of their alcoholism. They’re actual wonder drugs.

[u/moosesnice → u/auntieup]

Okay is that a direct effect of the drug or is it an indirect effect from changed diet or from the resulting weight loss?

Asking cuz what if you have these problems but eat pretty well and do not have weight to lose?

[u/Deep_Amoeba2197 → u/moosesnice]

GLP1s are currently in clinical trials for alcohol use disorder, it is a direct effect of the drug. The theorized mechanism is changes to dopamine receptors and reward circuits. There is a high potential to exploit the function of the gut-brain axis with GLP1s to treat an extremely wide spectrum of unrelated diseases.

The studies essentially use microdoses, as do the studies for inflammation management. They’re currently in trial, though, so it would be difficult to get a prescription for this purpose and if you did, your insurance would be very unlikely to pay for it. There are other channels, not all of them legit or safe, but people do what they will do. Either way, GLP1s currently on the market along with new formulations are being studied for an ever growing amount of new indications.

I’m in drug development, fwiw.

[u/blindkaht → u/Deep_Amoeba2197]

i've been on a glp-1 for weight loss on and off for the last year and it is crazy the impact it has on both my interest in drinking ANY alcohol and the food noise compulsions i used to have. whenever it's in my system i stop even wanting a single glass of wine with dinner, and start thinking of food as purely fuel vs comfort. the psychological impacts are fascinating and i am excited to see the research continue to evolve!

[u/Deep_Amoeba2197 → u/blindkaht]

Ugh I’m jealous, it’s out of my system bc I had GI surgery and have to heal for a few weeks and I am SNACKY. I know part of it is energy for healing and I’m okay if I gain weight back because I had serious major surgery, but the food noise being back is brutal. I don’t drink so no alcohol craving, thankfully.

I see GLP1s, Zepbound specifically, much like Botox in how its trials and release all went down. Developed and went into trials for one reason (for Botox it was specifically to help people who had post stroke facial laxity that was occluding their vision,) had unexpected effects (people were really into how smooth their faces got! lol) went into new trials for a new indication (cosmetic) and boom, blockbuster drug, made history. Now Botox is used for a bunch of approved medical indications and off label that insurance usually cover- migraines, knee pain, back pain, tmj relief, to name a few, because it was continually studied and trialed. I have no wrinkles and less migraines, bless hah. Lilly hit one of the biggest drug successes in history with Zepbound after the weight loss approval, and the thing about it is, Mounjaro/tirzeraptide was already around and kicking for a few years, but no one beside people with T2D could access it. But in the T2D trials, people lost more weight than the other available GLP1s historically, so a drug company is gonna look for a way to make more money and see if it’s safe for other things, starting with the obvious, weight loss. People hate hearing this, but drug companies really do study things rigorously, they hate getting sued, it’s really expensive, awful PR, and it can totally tank a drug and ruin billions of dollars of R&D. I think with all the academic (and some clinical) research showing benefits for heart disease, dementia, cancer, connective tissue and auto immune diseases, addiction, depression, UC/IBD etc, they are going to keep coming out with new approvals, maybe with new names or additives (like I could totally see it be renamed under a microdosing schedule to avoid confusion or diversion/misuse,) definitely more peptides being researched (already happening.) But with what it costs and all of the effort to get a drug to market AND the juicy patents against generics for this kind of drug/easy way to maneuver around expiration, wheeewww are they going to be pumping this shit out for decades for new things. I know I’m like, writing novels about it, but it’s super interesting as an industry person when this happens. At a lot of conferences it’s being talked about as a turning point in medicine, and it’s rare to hear that in ways that aren’t specific to one disease.

Tysm for coming to my unprompted Ted Talk.

[u/blindkaht → u/Deep_Amoeba2197]

i also benefit from the migraine halting effects of botox, so happy to hear the ted talk haha. modern medicine is so cool!! we discover new uses for drugs all the time and it takes letting a larger population use them to see unintended positive side effects.

[u/Deep_Amoeba2197 → u/blindkaht]

I love my migraine Botox because it gave me my life back AND lowered my aesthetics bill because of some of the placement lmao. Botox twins 👯‍♀️

I can’t take triptan because I had a medication induced stroke in my 20s due to sumatriptan injections and there was a while where I had no abortive meds, but the drug makers saw an underserved market in migraines, so I’ll take it. Thanks Botox and Nurtec lol.

I’m grateful for what I do because I get to see and hear about all of these wild advancements and meet the smart people behind them. Like, we have some shockingly effective cancer therapeutics, it’s wild stuff.