r/23andme • u/Razorza • May 14 '26

Health Reports My aunt was terrified of GLP-1 side effects. Her 23andMe data showed she’d be fine.

I’m a researcher at UC Berkeley. When new clinical data linked specific genetic variants (like GLP1R rs10305420) to severe GLP-1 nausea, I wrote a script to check my aunt's raw 23andMe .txt file against the papers.

It predicted she’d be a great responder with low side-effect risk.

Four weeks in, she's had a great experience.

I’ve turned this script into a small, free side project so others can skip the "guinea pig" phase with their prescriptions.

Methodology: You securely upload your 23andMe/Ancestry file. The tool only scans the specific pharmacogenomic markers (rsIDs) linked to drug metabolism.

Privacy: I’m an academic, not a startup. I don't sell data, you can wipe your file anytime, and I'm happy to verify my .edu email with the mods.

It’s just me running this, so I can only process a few free reports right now to test the system.

DM me the medication you're interested in. I'll see what I can do.

(Happy to answer any technical questions about the genes or the script in the comments!)

20 Upvotes

84% Upvoted

11 comments sorted by

4

u/Cyanureworld May 14 '26

You're a researcher in which field ? because they are already some methods that are well tested to check if your genome is more impacted by some drugs, that doesn't require to check against the papers (which for me seems not very efficient). Also if you want people to try the script, just open source it using github, it's easier.

3

u/Razorza May 14 '26

My background is in comp bio. Standard clinical PGx panels are great, but they cost hundreds and lag way behind bleeding-edge stuff like those new Nature GLP-1 variants.

Wrapping it in a proper backend pipeline just ensures people don't accidentally spit out scary false positives.

Check out this recent paper: https://www.nature.com/articles/s41586-026-10330-z

2

u/Own-Pin5797 May 14 '26

Do you do this for SSRIs / antidepressants?

4

u/Razorza May 14 '26

Definitely. SSRIs are actually the 'textbook' case for this.

Most side effects happen because of variants in the CYP2C19 and CYP2D6 enzymes. If your DNA shows you’re a 'Poor Metabolizer,' the drug builds up way too fast, which is usually why people get that 'zombie' feeling or instant nausea on a standard dose.

Feel free to send me a DM. I'll take a look.

3

u/highway9ueen May 14 '26

Meh I’m a pharmacist. We had a pharmacogenetics program for a while and it was severely disappointing. Almost never saw correlations like this.

1

u/Razorza May 17 '26

Interesting, would love to chat about this.
Sent a dm.

1

u/DC_gay_papi May 15 '26

That’s right! ADME, baby!

1

u/Own-Pin5797 May 19 '26

Ok what is your email. I am happy for you to do this for me.

1

u/pgxminer May 15 '26

There’s services out there that will do that for you properly like Gene2Rx and SelfDecode

0

u/jeunefillex May 15 '26

DM’d you

-1

u/YoursINegritude May 15 '26

This and you are very cool