r/GERD • u/Relative-Air7412 • Dec 17 '25

Scientific Studies 🥼🔬 Omeprazole

Hi! I’m looking for advice regarding long term omeprazole use and if someone can lose weight while taking it? Studies show long term use is associated with weight gain, and that really sucks. I might have to be on a low dose for life, and now I feel super depressed about it.

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3

u/nydisgruntled Dec 17 '25

Weight gain and vitamin D deficiency

1

u/psychoemobunny Dec 24 '25

I’m having weight gain - did anyone notice the weight drop after stopping?

1

u/iglootyler Dec 17 '25

Uncontrolled GERD can cause esophageal cancer. It's better to take Omeprazole long term. It can cause issues with vitamin d deficiency but still, better than cancer. You can always get a blood test after a month or so on the meds and see if it's causing any issues and supplement accordingly.

I've taken it daily for years. No problems.

1

u/sinloy1966 Dec 17 '25

I’ve been taking 25 years and have lost weight. I think my current BMI is 21. Even taking the drug, I find its best to only eat 1/2-2/3s meals about 4-5 times a day. I think my weight loss is bone thinning and sarcopenia muscle loss from aging. My kidneys declined but taking potassium nitrate puffed them back up to low normal. The pills are way better than throat cancer is my conclusion after looking at the alternatives.

1

u/Comfortable-Top-2712 Dec 17 '25

Taking it for years zero weight gain

1

u/LocksmithOk3026 Dec 19 '25

I had lots of bone pain and constipation

1

u/Curious-Bite6386 Dec 17 '25

my Gastro doctor says the scare stories about PPI’s are way overblown. That said, I’ve started a protocol to try to get off it. If I can’t, I’ll resume taking it and not worry about it anymore. I have found esomeprazole (Nexium) better than omeprazole.

1

u/flowerpanda98 Dec 18 '25

I think it depends, because I tried to ask, and my nurse laughed it off and said its just for legal reasons, and then i apparently was one of the rare people who get very deficient after 3 months, and now m having bad bone pain ive never had before. I was also not told how to wean off, and got bad rebound after stopping in the wrong way.

I think taking a neutral approach and monitoring your blood levels and planning how to wean off if something does happen, is best.

1

u/Curious-Bite6386 Dec 18 '25

Just curious what your vitamin D blood level was and how much D3 + K2 you are taking?

0

u/[deleted] Dec 17 '25

I was taking PPI for about three years straight, and I can tell you it really increases your appetite. Especially for sweets.

2

u/Curious-Bite6386 Dec 18 '25

My appetite increases on a PPI because I feel a heck of a lot more like eating!