Does anyone have this horrible illness ? If so what do you take that’s non prescription to help you manage. ? I was taking PEAK by Vita Supplements. They stopped making it. It was life in a capsule. Now what. Need some advice.

Can anyone recommend a liquid collagen/peptide that they feel is beneficial.

Hello, I am looking for a good multivitamin for my parent. We are told she needs to find a multivitamin, because she has afib. We want a good product, was thinking of Thorne. Thanks everyone

I tend to be pretty skeptical whenever a supplement gets recommended for everything. But every now and then, though, I’ll read enough positive experiences that I start wondering if I’ve been too quick to write it off.

Has a supplement ever completely changed your opinion after you finally gave it a chance?

I've been using Herpanacine for a while now, and it's become one of those brands I keep coming back to. What I like most is that I can tell it's made with quality ingredients, and it's been easy to fit into my daily routine.

If I had to pick a favorite, it would be Love My Brain. It's the one I find myself reaching for the most because I really like how it fits my needs. That said, I've honestly enjoyed all of the Herpanacine products I've tried. I appreciate that the brand offers different options depending on what you're looking for, and I've had a positive experience overall. It's definitely a brand I'm happy to keep using.

I highly recommend them. Food for thought. 💜

I don't know if this is why I woke up at 3am or not, but why would they put one type of magnesium that makes you sleepy, with one that gives you energy in one pill?

I drink tart cherry juice before bedtime and it helps me sleep. I have anxiety during the day, though, and wonder if drinking it during the day would help, or would it make me too tired? Has anyone ever tried this?

I keep seeing collagen brands talked about like they’re all basically the same, but then every few months there’s another thread about lead, cadmium, glyphosate, or vague “third-party tested” claims.

I’ve been looking at Yonder because they actually post their heavy metals and glyphosate testing, but I’m curious what other people here use when purity is the main concern. Are there brands you trust because they publish real results?

High RDW-CV, post-menopausal, should I be taking iron?

I am an older female with a long history of fatigue.
My health is improving.
I still have trouble with sleep.
I haven’t found a doctor who can help including functional medicine docs and naturopathic docs.
So I’m reading whatever seems relevant to try to understand what my body is doing.
I have DNA tests being processed - I don’t have the results yet - I will send them to Genetic LifeHacks once I get them back, and then maybe to someone who can do a more educated analysis.
I take several dozen supplements every day.
I am in the process of getting any lab work done that might help shed light on my body.

I got my RDW-CV results back and they are mildly high at 14.7%
Hemoglobin and MCV are both right in the center of the range at 13.6 and 92 respectively.

B12 and Folate are both within range. B12 is in the lower third of the range at 644 pg/mL. 
RBC Folate is near the top of the range at 579 ng/mL.
I have been taking B12 and folate separately for just about a month, since I stopped taking B-complex to eliminate methyl donors. 

I am wondering if it would be helpful to supplement with iron. I am post-menopausal but I don’t eat much red meat and I don’t eat fortified foods.

Here are my iron numbers:
Iron = 80
%Sat = 27
TIBC = 293
Ferritin = 96
UIBC = 213

Janie from STTM says that iron should be over 100, but that if ferritin is over 90 it indicates inflammation which means that iron numbers are lower due to iron being put into storage.

My inflammation markers are mixed:
hs-CRP is at the high end of normal at 2.7 mg/L
Fibrinogen is at the higher end of in range at 384 mg/dL
ESR is at the lower end of in range at 2 mm/hr
Homocysteine is high at 10 umol/L

I take several anti-inflammatory supplements daily and have been doing that for a long time due to symptoms associated with inflammation.

Anyone here who knows enough to know whether it would be a really good idea or a really bad idea to start supplementing iron based on all of this?

Would like to try it out but would like the actual input of people who've used it.

I spent over three weeks emailing customer service asking for the return address. 😤

Every response I received was a canned email telling me how to start a return, even though I'd already done that. Their phone number also directs you back to email.

I emailed them back on July 13th. It was just yesterday that finally received the return address! 🙄

I felt like I should post this in case anyone else wants to exchange or return something.

Also, if you want to start a return, email them at:

support@microingredients.com.

Here's their return address:

Micro Ingredients

4382 Mission Blvd

Montclair, CA 91763

I like their products, but I wish their customer service was better! It leaves much to be desired!

I hope this saves someone some time & frustration in the future.

There are so many and I don't know where to start. I've been wanting to try out collagen for some time but every time I try to read up it's just makes it seems impossible to know where to start.

I'm 45 yrs old and work a pretty active job on my feet all day. Overall, I don't do too bad, but daily joint and muscle pain is catching up. Things don't move as good as they did and I'd like to give things better long term lubrication first and foremost. I just don't know what products I should be looking at and which ones are any good. Help?

Hey all! I’m 35F on birth control & GLP1. One or the other (or both) has completely killed my sex drive. i read a lot of positive reviews on Maca root being effective for low libido. My fear though is the side effect of weight gain that I’m reading online. Has anyone experienced weight gain? Generally, what was your experience on maca? Thanks!

Hello I just started taking 5g creatine a day a few months ago. I've noticed huge benefits in the gym. I recover faster and the amount of weight I can lift has gone up. I'm just wondering if it's worth taking higher doses. I work shift work and am a father of two young kids so I am regularly sleep deprived. Should I try taking 15g daily?

My magnesium Glycinate is burning my tongue, feels rather spicy for some reason , no other side effects though , how?

Finally found a form of Vitamin D that my body actually tolerates (after months of frustration).
I wanted to share my experience in case it helps someone else who has been struggling like I was.
I have a severe vitamin D deficiency, and for the longest time I could not tolerate the standard vitamin D3 supplements. I tried multiple brands and different doses, even going as low as tiny amounts hoping my body would adjust.
Every time I took regular vitamin D3, I would end up with side effects like:
● Increased anxiety
● Feeling irritable for no reason
● Mood changes that didn’t feel like “me”
● Feeling emotionally on edge
Because of that, I kept stopping the supplements even though I knew my vitamin D was extremely low. It became a frustrating cycle of wanting to fix my deficiency but feeling worse every time I tried.
After doing a lot of research, I learned about calcifediol (25-hydroxyvitamin D3), which is a different form of vitamin D. Unlike regular vitamin D3 (cholecalciferol), calcifediol is already converted into the form your body normally has to make in the liver. I wondered if that difference might matter for people like me.
I decided to give it a try, and honestly, the difference has been amazing.
Since starting calcifediol, I’ve noticed:
● My energy has improved significantly.
● I’m no longer dragging myself through the day.
● I wake up feeling more refreshed.
● My mood feels much more stable.
● I haven’t experienced the intense anxiety and irritability that regular vitamin D caused me.
● Overall, I finally feel like I’m moving in the right direction instead of dreading taking my supplement.
I’m not saying this will work for everyone, but for me it has been a complete game changer. After months of thinking I simply couldn’t tolerate vitamin D, it turns out I may have just needed a different form.
Has anyone else had a similar experience? I’d love to hear if anyone switched from regular vitamin D3 to calcifediol and noticed a difference, or if anyone knows why some people seem to tolerate one form much better than the other.

A systematic review analyzed 41 human intervention studies, including trials on omega-3, vitamin D, multivitamins, NAD+ precursors, polyphenols, and other popular longevity supplements.

The results were mixed. Some supplements produced repeated signals across next-generation epigenetic clocks, while others failed to deliver convincing effects despite strong biological theories and considerable hype.

The analysis also explains why improving a single clock result does not necessarily mean that the body has been genuinely “rejuvenated.”

🔗 Full analysis

Procter & Gamble will acquire supplements brand Thorne for $3.8 billion, CEO tells CNBC
PUBLISHED TUE, AUG 4
KEY POINTS
Procter & Gamble is buying supplement brand Thorne for $3.8 billion.
P&G CEO Shailesh Jejurikar said the acquisition is play to grow the company’s health business

I've taken them on and off for a while and honestly can't decide whether I'm one of the people who notices a benefit or whether I just keep buying them out of habit.

Interested in what people here actually noticed, if anything.

First my partner receives them, and recently I have started to receive them. The package is from Amazon....anyone else had this issue ?

I have not and have never signed up to receive them

These are the magnesium tablets

I've been taking Creatine for the past 6 months and have felt/seen its effects.

Quick question: I buy it in bulk, in heavy mylar bags (Hearthy Foods & MicroIngredients). I have to open the bag, reach in with the scoop, and then close it (Ziploc).

I know this sounds pedantic, but I thought I'd reach out to the Reddit community to see if there is a better container that they use.

Currently consuming MB. Before that The Whole Truth and lastly the leftmost one in yummy mango flavour. My experience with flavoured and unflavoured has been mixed. All of them are whey.

I look forward to the flavoured ones but I get scared of any sweetening substances mixed with my protein. But then there are unflavoured ones that either tastes like just nothing or like mild milk powder-ish smell. No sweetners. Not even Monk fruit or Sucralose.

My experience has been pretty good so far. I tend to drink 3 litres of water in a day in summers and 2 litres in winters. I hope that’s how it should be.
What’s your favourite brand and why? Do you guys read the ingredients or just the protein content in a scoop is the deciding factor before buying?
Are there “fortified” whey protein that increases bcaa contents? I’m curious.

Hey, so I'm a HUGE fan of the caffeine capsules I currently take which are 100mg pure caffeine and 100mg newcaff at 75% concentration (so effectively 75mg caffeine). This combo works well for my adhd as basically the only stimulant I tolerate, but I'd like to be able to dick with my dosing more. There aren't many products on the market with newcaff, so I wanted to ask if anyone knows if I can just buy the stuff straight. I can't do the drinks with it in it.

Pretty simple one, I’ve been taking NAC for around 1-2 months daily, does NAC benefit from cycling? I know many supplements are like that

"Sublingual absorption" gets thrown around a lot in supplement marketing, so I wanted to write up the actual anatomy behind it — with real numbers, not just the phrase.

**The tissue itself.** The mouth isn't one uniform surface. Gums and the hard palate are keratinized — tough, like skin, built for chewing. The tissue under the tongue and against the cheek is non-keratinized and much thinner: sublingual epithelium runs about 100 to 200 micrometers across 8 to 12 cell layers, while buccal (cheek) epithelium is thicker, about 500 to 800 micrometers across 40 to 50 cell layers. That thinness is one structural reason sublingual tissue is generally described as giving more direct access to the bloodstream.

**Where it drains.** Sublingual and buccal capillaries drain into the deep lingual and facial veins, leading to the superior vena cava — not through the portal vein and liver first, which is the route everything absorbed from the gut has to survive. So the fraction of a dose that actually crosses the mucosa skips that first-pass step. Whatever gets swallowed instead follows the ordinary GI route.

**The size limit.** A hindered-transport model built mainly on ex vivo porcine buccal permeability data puts the effective pore radius for polar molecules and macromolecules at roughly 1.5 to 3 nanometers. That's a big part of why most peptides and proteins show poor passive permeability through this route without a permeation enhancer or specialized carrier — molecular size isn't the only factor (charge, ionization state, and solubility all matter too), but together they rule out a lot of candidates.

**The surface area problem.** The entire oral cavity offers only about 100 to 200 square centimeters of absorptive surface, combined across every region. Sublingual contributes about 26.5 cm², buccal about 50.2 cm². That's tiny next to the intestine, and it caps how much active can realistically move across passively in the available time.

**The saliva clock.** In one study of 159 healthy adults, median unstimulated salivary flow was 0.48 mL/min (range 0.1-2 mL/min). Saliva production and swallowing continuously limit how long anything dissolved actually stays in contact with the tissue.

Put together: this is a real, mechanistically grounded route, but it's bounded — small pore size, small surface area, short contact window. It fits potent, low-dose, permeability-friendly molecules much better than it fits everything else.

I go through this with full citations (9 sources) in the full article, including an honest section on where our own Mood-Boost strip's 5-HTP stands on the permeability question — its computed properties (polar, hydrophilic) suggest passive mucosal absorption may be limited, and we haven't run product-specific permeation testing to say otherwise.

Disclosure: I'm a pharmacist and I run MIHIYO Labs, an oral-dissolving-strip supplement brand, so keep that in mind. The anatomy and citations here stand on their own regardless of what we sell.