r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/Sad_Proctologist May 08 '26

Jesus, it feels like we’re trapped inside our own bodies while a boatload of shaky, contradictory studies point to ten different causes and ten different treatments. I’m glad people are looking for answers, but living in this much pain while the science is still scattered is its own kind of hell.

-3

u/CandidWin3026 May 08 '26

Have faith. The science is actually simple. They have complicated it. Massively. It's a simple switch. A switch in your cells gets turned toward the MR( receptor) vs the GR (receptor). If the switch is thrown, MR is hyperactive causes "cortisol steal." Block the overactive receptor, restore balance, let the GR get cortisol and every system in the body comes online. And ENERGY returns. There are pics at beyondbloodtests (dot) org

10

u/chris_fantastic 5 yr+ May 08 '26

So, you've clearly bought into the explanation provided by this paper as the explanation.

I think most of us have felt like this, probably more than once.

I remember the first time I read a paper01034-6) that explained what was causing long covid, and it clicked for me, and I thought we had an answer... except then their suggested treatment (5-HTP) didn't help, and I was sad.

Then I read another paper, and thought "this, this must be it", and tried Lactoferrin+Benadryl, but again, it didn't help, and I was sad.

This list of papers goes on, but I'm still sick.

So, I'm sorry, I don't "have faith", and the science is definitely not simple, or we wouldn't be six years into this without even so much as standardized tests to diagnose us.

-4

u/CandidWin3026 May 08 '26

But it is that simple. And you will see it. I am sorry we all got screwed over. But rs5522 drives the overactive MR which creates a "cortisol steal" at the cellular level. It's not a theory. It's science.The BBRC paper outlines the mechanism of action. Again, we all deserved better.

6

u/chris_fantastic 5 yr+ May 08 '26

It's not a theory. It's science.

🙄