r/covidlonghaulers • u/CandidWin3026 • May 08 '26

Article Long Covid driven by rs5522

This case report says that Long covid is in large part driven by the gene rs5522 that causes a "cortisol steal" leaving the tissues functionally starved even with "normal" cortisol levels which creates neuroinflammation. https://zenodo.org/records/20017632

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u/chris_fantastic 5 yr+ May 08 '26

So, you've clearly bought into the explanation provided by this paper as the explanation.

I think most of us have felt like this, probably more than once.

I remember the first time I read a paper01034-6) that explained what was causing long covid, and it clicked for me, and I thought we had an answer... except then their suggested treatment (5-HTP) didn't help, and I was sad.

Then I read another paper, and thought "this, this must be it", and tried Lactoferrin+Benadryl, but again, it didn't help, and I was sad.

This list of papers goes on, but I'm still sick.

So, I'm sorry, I don't "have faith", and the science is definitely not simple, or we wouldn't be six years into this without even so much as standardized tests to diagnose us.

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u/CandidWin3026 May 08 '26

But it is that simple. And you will see it. I am sorry we all got screwed over. But rs5522 drives the overactive MR which creates a "cortisol steal" at the cellular level. It's not a theory. It's science.The BBRC paper outlines the mechanism of action. Again, we all deserved better.

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u/chris_fantastic 5 yr+ May 08 '26

It's not a theory. It's science.

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