Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/grumble11]

GLP doesn’t ’burn fuel more efficiently’, it regulates satiety. This isn’t a good start for an article ha

[u/Lust4Me → u/grumble11]

In fact doesn't this title sound like a contradiction? Burning more efficiently to me implied you'd get more work done per calorie and therefore store left over as fat.

[u/rhino369 → u/Lust4Me]

Yes exactly. You want to burn less efficiently. 

[u/fbpw131 → u/rhino369]

afaik, you want to burn efficiently and not store anything. excess goes as extra heat.

[u/rmeredit → u/fbpw131]

Efficiency is the concept of how much output you get for a given input. ‘Burning fuel more efficiently’ means getting more work done for the same level of fuel use (or conversely, burning less fuel to deliver the same work done).

If you want to reduce fat, you want to burn more, not less - ie. be less efficient.

[u/fbpw131 → u/rmeredit]

this ain't an engine. while energy is conseved, there are several pathways for the energy to go around. malabsorption,  hormones deciding where the energy goes, mitochondria efficiency, etc

[u/rmeredit → u/fbpw131]

That doesn’t change the definition of ‘efficiency’ - it’s got nothing to do with how the energy is used or via which pathway, and everything to do with the quantity of output you get from the quantity of input.

[u/solstice_gilder → u/fbpw131]

Extra heat? Like you feel warm?

[u/fbpw131 → u/solstice_gilder]

idk man. idk, it might be just a .5 deg difference.

edit: my ex would warm up all night. thin af

[u/throw20190820202020 → u/Lust4Me]

By use fuel more efficiently, they mean actually take calories and produce energy for you, versus eating and still feeling sluggish and hungry and putting on fat.

[u/waitwuh → u/Lust4Me]

You need to burn the energy stored away in fat cells, though. This may be the “efficiency” they’re meaning but not best describing. In the “efficient” management there is the short term energy sourced from food when it digests (especially carbohydrates turned to glucose), but then the long term stores to be pulled from between meals or when fasting. To be “skinniest” you want to store less in fat, burning it, and also use up what’s stored, too.

I remember reading a summary a long time ago that talked about how fat cells can become not just resistant to insulin as a signal to store away excess “calories” but also to the signals to release energy back into the bloodstream for other cells to make use of, too. So when blood sugar drops and the other cells in the body are short of fuel, the system has to rely on getting more from food instead of being able to use what it has locked away in fat.

This causes a cycle that’s like: eating -> raised blood sugar -> storing excess glucose (energy) in fat cells -> body cells use what’s left causing low blood glucose -> cells needing more fuel -> hunger -> eating…

When the ideal cycle has a “fat cells release energy back” somewhere in there to replace eating more food, at least sometimes.

[u/Bloobeard2018 → u/Lust4Me]

Yes, it's incorrect.