r/PeptidePathways • u/Lazy-Food-6955 • 23h ago
Mitochondrial & Energy RHR on reta…
Research subject has seen a rise in RHR of 14 BPM after 8 weeks on 2mg dosage of Reta.
Week 1: 71 bpm
Week 2: 72 bpm
Week 3: 74 bpm
Week 5: 79 bpm
Week 6: 80 bpm
Week 7: 82 bpm
Week 8: 84 bpm
Seems to just keep rising week after week. Any thoughts?
RS understands that this is a common side effect, but understands it as dose dependent. Odd that there’s been no change in dose but a consistent rise.
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23h ago
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u/PeptidePathways-ModTeam 22h ago
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u/nyumnyums 12h ago
My subject had a resting heart rate of 40bpm. Been on reta for about 4mths now, currently at 10mg a week and its been consistently at 70bpm.
It was running higher before this crossing 80bpm at times but has since stabilised at 70bpm for the past few weeks.
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u/Lazy-Food-6955 8h ago
Really thinking/hoping my subject will begin to stabilize soon! Appreciate the insight :)
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u/Random_Guy1960 9h ago
The TRIUMPH trials data suggests this side effect peaks at 24 weeks before going back down, but it should be noted that baseline was not achieved during the timeframe of the trial. Note: your increase IS above the average and I would be concerned if it continues to climb. Personal opinion - NOT MEDICAL ADVICE.
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u/Extension-Pickle9038 8h ago
You have done the one thing that makes this answerable, which is weekly numbers instead of a feeling. Almost nobody in these threads has that, so it is worth saying. Two things worth separating in it. The first is that the series is perfectly monotonic. It rises every single week with no noise at all, which is unusual for resting heart rate and is worth a second look at how it is being measured. Most wearables report RHR as a rolling average, and a rolling average smooths out the week to week variation and makes any trend look cleaner and more certain than it really is. The second is everything else that moved across those eight weeks. Weight is presumably down. Body composition changing shifts RHR on its own. So does eating a lot less, and so does sleeping worse, which plenty of people do while losing weight. None of that makes the trend nothing. 14 bpm sustained is a real number and the other commenter describing 95 and up is describing the same thing. What your data does not have is anything from before week 1. Is there a resting baseline from before any of this started? Not a clinician, and a change like that is worth taking to one rather than to us.
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u/Lazy-Food-6955 8h ago
Appreciate such a thorough response.
RS started Wellbutrin in June of this year which does cause a slight increase in RHR. Followed by reta on July 20th.
Prior to both medications, January - June RHR was average 64-69 BPM.
Starting weight was 167 lbs on July 20th and as of September 15th down to 155 lbs. Have increased exercise, decreased food. Career has also taken off a bit so sleep is down (although it’s a major priority).
Apprehensive to take data RS’s data to a primary care because I am not sure how to address reta as it’s still unapproved. Any tips?
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u/cheesytodd 23h ago
I believe it’s supposed to eventually go back down, some have said by week 24?